Individualised MRI training for paediatric neuroimaging in autism spectrum disorders: A child-focused approach

BioRxiv : the Preprint Server for Biology
Emmanuel Peng Kiat PuaMarc Seal

Abstract

Magnetic Resonance Imaging (MRI) is a non-invasive method to study brain structure and function and has been widely used to understand atypical brain development in neurodevelopmental disorders. However, paediatric MRI imaging in children is often complicated by willingness to enter the scanner and motion-related imaging artefacts. The scanner environment is highly unusual and may worry a younger cohort, especially in children with sensory sensitivity and separation anxiety. The issue is more challenging in children with Autism Spectrum Disorders (ASD), where delivery of instructions for novel task demands in an unfamiliar setting may be limited or less effective due to communication disorder or intellectual disability. These issues together often give rise to excessive head motion that can significantly reduce the quality of images acquired, or render data unusable. Here we report an individualised MRI training procedure that enables young children with ASD to better tolerate the MRI scanner environment based on a child-focused approach and an individualised familiarisation strategy. The training procedure was implemented in a locally recruited study of monozygotic twins (n=12; 6 twin pairs; age range 7.1 to 12.85 years) conco...Continue Reading

Related Concepts

Brain
Diagnostic Imaging
Head Neoplasms
Magnetic Resonance Imaging
Physiological Aspects
Scanning Systems
Cohort
Neuroimaging
Brain Development
Population Group

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