Individualised Multimodal Treatment Strategies for Anaplastic and Poorly Differentiated Thyroid Cancer

Journal of Clinical Medicine
Sabine WächterPietro Di Fazio

Abstract

The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) panobinostat in patient-derived tumor tissue (PDTT) of ATCs/PDTCs, the expression of sodium iodide symporter (NIS) and radioiodine up-take (RAI-U). High Mobility Group AT-Hook 2 (HMGA2) and associated miRNAs expression was correlated with the clinical course of the patients. Inhibitory effects of panobinostat, sorafenib and selumetinib were measured by real time cell analyser xCELLigence in five PDTTs and human foreskin fibroblasts (HF) used as control. Expression of NIS, HMGA2 and associated miRNAs hsa-let-7f-5p, hsa-let-7b-5p, hsa-miR-146b-5p and hsa-miR-146b-3p was performed by RT-qPCR and Western blot. RAI-U was performed by Gamma Counter with I-131. Panobinostat showed the strongest cytotoxic effect (10 nM) in all PDTTs and HF and caused a significant over-expression of NIS transcript. TKIs were able to up-regulate NIS transcript in patient 5 and in HF. RAI-U was up...Continue Reading

References

Feb 18, 2003·Endocrine Reviews·Orsolya DohánNancy Carrasco
May 27, 2006·Endocrine-related Cancer·P PallanteA Fusco
Jun 13, 2006·Cancer Cell·Monica FedeleAlfredo Fusco
May 8, 2007·World Journal of Surgery·Brian Hung-Hin Lang, Chung-Yau Lo
Dec 4, 2009·Translational Oncology·Júlio Cezar Marques Ricarte-FilhoEdna Teruko Kimura
Mar 30, 2010·Molecular and Cellular Endocrinology·Monica FedeleAlfredo Fusco
Mar 15, 2011·International Journal of Cancer. Journal International Du Cancer·Maria Graziella CatalanoGiuseppe Boccuzzi
Jul 21, 2011·Journal of Oncology·Govardhanan NagaiahScot C Remick
Dec 25, 2012·The Journal of Clinical Endocrinology and Metabolism·Chen-Kai ChouRue-Tsuan Liu
Jan 9, 2013·Arquivos brasileiros de endocrinologia e metabologia·Murilo Vieira GeraldoEdna Teruko Kimura
Feb 15, 2013·The New England Journal of Medicine·Alan L HoJames A Fagin
Mar 28, 2013·Thyroid : Official Journal of the American Thyroid Association·Mariateresa PuglieseMaria Graziella Catalano
Jun 21, 2013·The Journal of Clinical Endocrinology and Metabolism·Michal SwierniakKrystian Jazdzewski
Jul 5, 2013·Journal of Cancer Research and Clinical Oncology·Daniel ChanH Phillip Koeffler
Sep 10, 2014·International Journal of Endocrinology·Cesar Seigi Fuziwara, Edna Teruko Kimura
Nov 19, 2014·Endocrine-related Cancer·Aparna LakshmananSissy M Jhiang
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
Dec 31, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xianzhao DengYouben Fan
Apr 11, 2015·Frontiers in Medicine·Pierlorenzo PallanteAlfredo Fusco
Mar 11, 2016·Journal of Cancer Research and Clinical Oncology·Alexander I DamanakisPietro Di Fazio
May 22, 2016·Endocrine-related Cancer·David ViolaRossella Elisei
May 30, 2017·Molecular and Cellular Endocrinology·Thanyawat SasanakietkulTobias Carling
Nov 1, 2017·Frontiers in Endocrinology·Chae Moon Hong, Byeong-Cheol Ahn
Mar 22, 2018·Journal of Clinical Medicine·Sabine WächterPietro Di Fazio

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Citations

Jul 6, 2020·Cancer Biomarkers : Section a of Disease Markers·Kevin SheeAngeline S Andrew
Jul 19, 2018·International Journal of Molecular Sciences·Sabine WächterPietro Di Fazio
Sep 17, 2018·Cell Communication and Signaling : CCS·Yan WuJulia Li Zhong
Feb 13, 2019·Thyroid : Official Journal of the American Thyroid Association·Tihana IbrahimpasicIan Ganly
May 6, 2020·International Journal of Molecular Sciences·Uchenna UnachukwuJeanine D'Armiento

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surgical resection
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