PMID: 3757785Sep 1, 1986Paper

Individualization of theophylline dosage in adults with bronchial asthma

Drug Intelligence & Clinical Pharmacy
M J OteroA Dominguez-Gil

Abstract

The influence of age on the disposition of theophylline was studied in 95 adult patients (nonsmokers) with bronchial asthma requiring oral theophylline therapy: 17 patients age less than or equal to 39 years, 50 patients age 40-59 years, and 28 patients greater than or equal to 60 years. A decrease was observed in total body clearance together with an increase in the elimination half-life of theophylline parallel to the advance in age of the patients. The apparent volume of distribution of theophylline was similar in the three groups of patients. According to the results obtained, recommendations are made regarding the dosage regimens of theophylline in elderly patients.

References

Jun 1, 1978·Clinical Pharmacology and Therapeutics·B H Dvorchik, E S Vessell
Jan 1, 1976·Clinical Pharmacokinetics·J CrooksI H Stevenson
Jun 5, 1975·The New England Journal of Medicine·K M Piafsky, R I Ogilvie
May 1, 1976·The Journal of Pediatrics·P M LoughnanA H Neims
Jan 1, 1983·European Journal of Clinical Pharmacology·S H Jackson, J M Wright
Jan 1, 1982·The Journal of Pediatrics·R CabanasJ Tojo
Nov 1, 1981·British Journal of Clinical Pharmacology·E J AntalI R Lawson
Jan 1, 1981·European Journal of Clinical Pharmacology·T TalsethJ E Bredesen
Aug 1, 1980·British Journal of Clinical Pharmacology·B CusackK O'Malley
Sep 1, 1980·British Journal of Clinical Pharmacology·G E MarlinP J Thompson

❮ Previous
Next ❯

Citations

Apr 1, 1996·Journal of Clinical Pharmacy and Therapeutics·M J OteroA Dominguez-Gil
Jul 1, 1988·Drug Intelligence & Clinical Pharmacy·M J OteroA Dominguez-Gil
Aug 1, 1988·Journal of Clinical Pharmacy and Therapeutics·M J OteroA Dominguez-Gil
Apr 12, 2016·Breathe·Salvatore BattagliaNicola Scichilone
Mar 18, 2016·Expert Review of Clinical Pharmacology·Fabio AgustaNicola Scichilone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.