Individualized 131I-mIBG therapy in the management of refractory and relapsed neuroblastoma

Nuclear Medicine Communications
Sally L GeorgeGlenn D Flux

Abstract

Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate response and toxicity following a dosimetry-based, individualized approach. A review of 44 treatments in 25 patients treated with I-mIBG therapy was performed. Patients received I-mIBG therapy following relapse (n=9), in refractory disease (n=12), or with surgically unresectable disease despite conventional treatment (n=4). Treatment schedule (including mIBG dose and number of administrations) was individualized according to the clinical status of the patient and dosimetry data from either a tracer study or previous administrations. Three-dimensional tumour dosimetry was also performed for eight patients. The mean administered activity was 11089±7222 MBq and the mean whole-body dose for a single administration was 1.79±0.57 Gy. Tumour-absorbed doses varied considerably (3.70±3.37 mGy/MBq). CTCAE grade 3/4 neutropenia was documented following 82% treatments and grade 3/4 thrombocytopenia following 71% treatments. Further acute toxicity was found in 49% of patients. All acute toxicities resolved with appropria...Continue Reading

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Citations

Feb 24, 2018·The British Journal of Radiology·James R Ballinger
Jul 31, 2020·Nature Reviews. Drug Discovery·George SgourosJessie R Nedrow
Jun 18, 2020·Frontiers in Medicine·Pedro M RubioLeopoldo Martínez
Jan 6, 2017·The British Journal of Radiology·Glenn D FluxKevin M Prise
May 15, 2019·International Journal of Molecular Sciences·Jongho Jeon
Jun 3, 2020·International Journal of Molecular Sciences·Andrea CiminiOrazio Schillaci
Oct 13, 2020·Nuclear Medicine Communications·Tara HaddadReza Vali
Dec 5, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·J Buscombe

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Methods Mentioned

BETA
surgical resection

Software Mentioned

Qrius
GraphPad Prism
EGSnrc
GraphPad
EGS + +

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