Individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP study): a randomized, double-dummy, double-blind, placebo-controlled trial.

PloS One
Emma del Carmen Macías-CortésJuan Asbun-Bojalil

Abstract

Perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased risk of depression. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopausal women. The aim of this study was to assess efficacy and safety of individualized homeopathic treatment versus placebo and fluoxetine versus placebo in peri- and postmenopausal women with moderate to severe depression. A randomized, placebo-controlled, double-blind, double-dummy, superiority, three-arm trial with a 6 week follow-up study was conducted. The study was performed in a public research hospital in Mexico City in the outpatient service of homeopathy. One hundred thirty-three peri- and postmenopausal women diagnosed with major depression according to DSM-IV (moderate to severe intensity) were included. The outcomes were: change in the mean total score among groups on the 17-item Hamilton Rating Scale for Depression, Beck Depression Inventory and Greene Scale, after 6 weeks of treatment, response and remission rates, and safety. Efficacy data were analyzed in the intention-to-treat population (ANOVA with Bonferroni post-hoc t...Continue Reading

Associated Clinical Trials

Jul 9, 2012·Emma del Carmen Macías-Cortés, MD, PhD, Emma del Carmen Macías-Cortés, MD, PhD

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Citations

Feb 19, 2016·American Journal of Public Health·Michelle L DossettGloria Y Yeh
Mar 23, 2017·Homeopathy : the Journal of the Faculty of Homeopathy·Peter Fisher
Apr 6, 2018·MMW Fortschritte der Medizin·André-Michael Beer
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Aug 11, 2020·Homeopathy : the Journal of the Faculty of Homeopathy·Emma Del Carmen Macías-CortésJuan Asbun-Bojalil
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Nov 3, 2020·Homeopathy : the Journal of the Faculty of Homeopathy·Robert T Mathie

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Methods Mentioned

BETA
hormone replacement therapy

Clinical Trials Mentioned

NCT01635218

Software Mentioned

Power
SPSS
Synthesis Homeopathic Repertory

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