Individualized Medication Management in Ontario Long-Term Care Clinical Impact on Management of Depression, Pain, and Dementia.

Journal of the American Medical Directors Association
Ruslan DorfmanAndrea Moser

Abstract

Assess the potential benefits of identifying drug-gene interactions in nursing home (NH) residents on multiple medications. Reduce the use of high-risk medications for residents with reduced drug metabolism. Open-label, nonrandomized, mixed methods study. Four NHs in Ontario. Potential drug therapy problems (DTPs) for study cohort were identified during a medication review by a pharmacist using pharmacogenetic (PGx) clinical decision support to identify medication change opportunities. The number of DTPs identified during a standard medication review was compared with the number of DTPs identified with a PGx clinical decision support. Analysis of medication dispensing data at enrollment compared with dispensing in a 60-day window following medication review were compared for the PGx-tested study cohort with controls. Prescription patterns of 90 study participants were compared with 895 controls for the same time period. Study participants were on 7 to 47 drugs, of which drugs with PGx indications ranged from 1 to 17 medications. The average medication load was 4.6 medications with PGx indications per person, whereas the controls were on 3.5 PGx drugs. Furthermore, 94% of cases and 84% of controls were on 2 or more drugs with PG...Continue Reading

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Citations

Apr 30, 2021·Frontiers in Psychiatry·William H RoughanMiguel E Rentería
May 21, 2021·Pharmacogenomics·Federico Rodriguez CairoliAgustín Ciapponi
Jun 17, 2020·Journal of the American Medical Directors Association·Philip D Sloane, Sheryl Zimmerman
Jul 23, 2021·Pharmacogenomics and Personalized Medicine·Susanne B HagaDeepak Voora
Jul 17, 2021·The Australian and New Zealand Journal of Psychiatry·Adrián I CamposMiguel E Rentería
Jul 17, 2021·PloS One·Candyce HamelBrian Hutton
Sep 4, 2021·Research in Social & Administrative Pharmacy : RSAP·Meagan HayashiSherif Hanafy Mahmoud

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