Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M D GeorgitsiHellenic Sepsis Study Group

Abstract

Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulatin...Continue Reading

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Citations

Oct 12, 2016·Scientific Reports·Tamara V SmelayaLyubov E Salnikova
Oct 11, 2019·Clinical and Experimental Medicine·Peng FuXiangcheng Zhang
May 31, 2018·BMC Infectious Diseases·Dimitrios SinapidisEvangelos J Giamarellos-Bourboulis
Aug 18, 2016·Expert Review of Anti-infective Therapy·Florian UhleGeorg F Weber
Jun 17, 2021·Nature Reviews. Urology·Ines AmbiteCatharina Svanborg

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