Individualized Titanium Mesh Combined With Platelet-Rich Fibrin and Deproteinized Bovine Bone: A New Approach for Challenging Augmentation

The Journal of Oral Implantology
Jonas LorenzShahram Ghanaati

Abstract

Autologous bone transfer is regarded as the gold standard for ridge augmentation before dental implantation, especially in severe bony defects caused by tumor resection or atrophy. In addition to the advantages of autologous bone, transplantation has several disadvantages, such as secondary operation, increased morbidity and pain. The present study reports, for the first time, a combination of a xenogeneic bone substitute (BO) with platelet-rich fibrin (PRF), which is a fully autologous blood concentrate derived from the patient's own peripheral blood by centrifugation. Solid A-PRF+ and liquid i-PRF together with an individualized 3-D planned titanium mesh were used for reconstruction of a severe tumor-related bony defect within the mandible of a former head and neck cancer patient. The BO enriched with regenerative components from PRF allowed the reconstruction of the mandibular resective defect under the 3-D mesh without autologous bone transplantation. Complete rehabilitation and restoration of the patient's oral function were achieved. Histological analysis of extracted bone biopsies confirmed that the new bone within the augmented region originated from the residual bone. Within the limitations of the presented case, the a...Continue Reading

References

Sep 1, 1984·Journal of Clinical Periodontology·J GottlowJ Lindhe
Nov 9, 2010·Foot and Ankle Clinics·Christopher W DiGiovanni, James M Petricek
Jun 20, 2014·The Journal of Oral Implantology·Shahram GhanaatiJoseph Choukroun
May 9, 2015·Oral and Maxillofacial Surgery Clinics of North America·Alan S Herford, Katina Nguyen
Nov 26, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Tomoki SumidaYoshihide Mori
Feb 7, 2017·International Journal of Molecular Sciences·Xuzhu WangRichard J Miron
May 17, 2017·Journal of Tissue Engineering and Regenerative Medicine·Eva DohleShahram Ghanaati
Jul 28, 2017·International Journal of Implant Dentistry·K SaghebW Wagner
Oct 27, 2017·Journal of Materials Science. Materials in Medicine·Simon WendShahram Ghanaati

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Citations

Feb 8, 2019·Journal of Periodontology·Richard J MironShahram Ghanaati
Feb 19, 2020·The Journal of Oral Implantology·Sarah Al-MaawiShahram Ghanaati
Oct 21, 2020·Clinical Implant Dentistry and Related Research·Songhang LiXiaoxiao Cai
Mar 18, 2021·International Journal of Oral Science·Bowen TanJinfeng Liao

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