Individualizing pharmacotherapy in patients with renal impairment: the validity of the Modification of Diet in Renal Disease formula in specific patient populations with a glomerular filtration rate below 60 ml/min. A systematic review

PloS One
Willemijn L EppengaPeter A G M De Smet

Abstract

The Modification of Diet in Renal Disease (MDRD) formula is widely used in clinical practice to assess the correct drug dose. This formula is based on serum creatinine levels which might be influenced by chronic diseases itself or the effects of the chronic diseases. We conducted a systematic review to determine the validity of the MDRD formula in specific patient populations with renal impairment: elderly, hospitalized and obese patients, patients with cardiovascular disease, cancer, chronic respiratory diseases, diabetes mellitus, liver cirrhosis and human immunodeficiency virus. We searched for articles in Pubmed published from January 1999 through January 2014. Selection criteria were (1) patients with a glomerular filtration rate (GFR) < 60 ml/min (/1.73 m2), (2) MDRD formula compared with a gold standard and (3) statistical analysis focused on bias, precision and/or accuracy. Data extraction was done by the first author and checked by a second author. A bias of 20% or less, a precision of 30% or less and an accuracy expressed as P30% of 80% or higher were indicators of the validity of the MDRD formula. In total we included 27 studies. The number of patients included ranged from 8 to 1831. The gold standard and measurement...Continue Reading

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Citations

May 29, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Nishank Jain, Robert F Reilly
Jan 28, 2015·World Journal of Hepatology·Ahmad Najib AzmiRosmawati Mohamed
Oct 30, 2016·British Journal of Clinical Pharmacology·Thomas TsaganosEvangelos J Giamarellos-Bourboulis

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Methods Mentioned

BETA
pharmacotherapy
urine collections
amputation
urine collection

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