Individually-matched etiologic studies: classical estimators made new again

European Journal of Epidemiology
James A Hanley

Abstract

With greater access to regression-based methods for confounder control, the etiologic study with individual matching, analyzed by classical (calculator) methods, lost favor in recent decades. This design was costly, and the data sometimes mis-analyzed. Now, with Big Data, individual matching becomes an economical option. To many, however, conditional logistic regression, commonly used to estimate the incidence density ratio parameter, is somewhat of a black box whose output is not easily checked. An epidemiologist-statistician pair recently proposed a new estimator that is easily applied to data from individually-matched series with a 2:1 ratio (and no other confounding variables) using just a hand calculator or spreadsheet. Surprisingly-or possibly not-they overlooked classical estimators developed in earlier decades. This prompts me to re-introduce some of these, to highlight their considerable flexibility and ease of use, and to update them. Nowadays, for any matching ratio (M:1), the Maximum Likelihood result can be easily computed from data gathered under the matched design in two different ways, each using just the summary data. One is via any binomial regression program that allows offsets, applied to just M 'rows' of da...Continue Reading

References

Feb 1, 1976·American Journal of Epidemiology·O Miettinen
Nov 1, 1986·American Journal of Epidemiology·J RobinsN E Breslow
May 24, 2003·Biometrics·Norman E Breslow
May 1, 1956·Annals of Human Genetics·J B HALDANE
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Sep 17, 2008·American Journal of Epidemiology·Mirjam J KnolMatthias Egger
Oct 10, 2012·International Journal of Epidemiology·Jan P Vandenbroucke, Neil Pearce
Oct 10, 2012·International Journal of Epidemiology·Jan P Vandenbroucke, Neil Pearce
Feb 27, 2016·BMJ : British Medical Journal·Neil Pearce
Mar 24, 2016·The New England Journal of Medicine·Kristian B FilionUNKNOWN CNODES Investigators
Aug 28, 2016·Journal of Clinical Epidemiology·Donald A Redelmeier, Robert J Tibshirani
Mar 10, 2017·European Journal of Epidemiology·Olli S Miettinen
Nov 5, 2017·European Journal of Epidemiology·Mohammad Ali MansourniaSander Greenland

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