PMID: 6113266Jan 1, 1981Paper

Individually reared rats: alteration in noradrenergic brain functions

Journal of Neural Transmission
K KraeuchiH Feer

Abstract

The influence of social isolation in rats on postsynaptic alpha 1- and beta-adrenergic receptors, on the cAMP generating system and on the presynaptic uptake mechanism in the central noradrenergic system was examined in different brain regions. Rearing rats in isolation from the 19th day of life for 12 weeks leads in all regions to a general tendency for a reduction in 3H-DHA binding, to an enhanced 3H-WB4101 binding and to a decreased responsiveness of the noradrenaline sensitive cAMP generating system. These changes reach significant only in the pons-medulla-thalamus region. Isolated rats showed an increased synaptosomal uptake of noradrenaline, most pronounced and significant in the hypothalamus. Our data provide further support for a disturbance in central noradrenergic function in isolated rats.

References

Jul 1, 1979·Brain Research·S T Mason, S D Iversen
Oct 1, 1977·Pharmacological Research Communications·J DavidR S Grewal
Nov 1, 1965·Journal of Neurochemistry·E GellerJ F Zolman
Jan 1, 1981·Progress in Clinical and Biological Research·P R BaryC B Brendler
Aug 1, 1981·Physiology & Behavior·C GentschH Feer

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Citations

Aug 1, 1981·Physiology & Behavior·C GentschH Feer
Jan 1, 1987·Physiology & Behavior·J OehlerJ Schmidt
Aug 1, 1984·Pharmacology, Biochemistry, and Behavior·J OehlerJ Schmidt
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·E A Stone
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·K E StevensG M Rose
May 21, 2005·Neuropsychobiology·Maria Luiza Nunes Mamede RosaMarcus Lira Brandão
Jan 1, 1989·Physiology & Behavior·G H JonesC A Marsden
Nov 30, 2005·Journal of Neuroscience Methods·Fernanda Mariana TomaziniMarcus Lira Brandão

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