Individuals with obesity but no other metabolic risk factors are not at significantly elevated all-cause mortality risk in men and women

Clinical Obesity
Jennifer L KukChris I Ardern

Abstract

Studies have examined mortality risk for metabolically healthy obesity, defined as zero or one metabolic risk factors but not as zero risk factors. Thus, we sought to determine the independent mortality risk associated with obesity or elevated glucose, blood pressure or lipids in isolation or clustered together. The sample included 54 089 men and women from five cohort studies (follow-up = 12.8 ± 7.2 years and 4864 [9.0%] deaths). Individuals were categorized as having obesity or elevated glucose, blood pressure or lipids alone or clustered with obesity or another metabolic factor. In our study sample, 6% of individuals presented with obesity but no other metabolic abnormalities. General obesity (hazard ratios [HR], 95% CI = 1.10, 0.8-1.6) and abdominal obesity (HR = 1.24, 0.9-1.7) in the absence of metabolic risk factors were not associated with mortality risk compared to lean individuals. Conversely, diabetes, hypertension and dyslipidaemia in isolation were significantly associated with mortality risk (HR range = 1.17-1.94, P < 0.05). However, when using traditional approaches, obesity (HR = 1.12, 1.02-1.23) is independently associated with mortality risk after statistical adjustment for the other metabolic risk factors. Sim...Continue Reading

References

May 1, 1992·European Journal of Epidemiology·G Assmann, H Schulte
Dec 1, 1984·International Journal of Epidemiology·A KeysG Farchi
Jan 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·U GoldbourtJ H Medalie
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Dec 6, 2001·Metabolism: Clinical and Experimental·E A Sims
Nov 26, 2002·Journal of the American College of Cardiology·Nazneem N WahabUNKNOWN ICONS Investigators
Aug 28, 2003·Scandinavian Journal of Clinical and Laboratory Investigation·E M HjerkinnH Arnesen
Feb 27, 2004·The American Journal of Clinical Nutrition·Ian JanssenRobert Ross
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Apr 25, 2006·Journal of the American College of Cardiology·Javed ButlerUNKNOWN Health ABC Study
Sep 22, 2007·Health Education Research·Rebecca M PuhlKelly D Brownell
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W P T James
Feb 4, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A M Sharma, R F Kushner
Sep 5, 2009·Diabetes Care·Jennifer L Kuk, Chris I Ardern
Dec 4, 2013·Annals of Internal Medicine·Caroline K KramerRavi Retnakaran
Nov 21, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R E Brown, J L Kuk
Jan 1, 2015·The Australasian Medical Journal·Lee Stoner, Jon Cornwall
Sep 16, 2017·Journal of the American College of Cardiology·Rishi CaleyachettyKrishnarajah Nirantharakumar
Nov 21, 2017·The Medical Clinics of North America·Kevin D Hall, Scott Kahan

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Citations

May 6, 2019·Journal of Cellular Physiology·Yu-Xiang WangLi Qin
Mar 5, 2020·Endocrine Reviews·Matthias Blüher
May 9, 2019·Hypertension·Elisabeth A LambertGavin W Lambert
Sep 17, 2019·The Journal of Clinical Investigation·Gordon I SmithSamuel Klein
Jun 25, 2020·Journal of Surgical Case Reports·Vladislav Pavlovich ZhitnyFrank Stile
Mar 25, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chunxiao LiaoLiming Li
Jul 8, 2021·American Journal of Physiology. Endocrinology and Metabolism·Joseph Bagi SuleimanMahaneem Mohamed

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