Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma

British Journal of Cancer
C AbelsR M Szeimies

Abstract

Indocyanine green (ICG) is clinically approved for the determination of liver function, cardiac output and plasma volume. In this pilot study, ICG was used as photosensitizer in combination with a diode laser to treat AIDS-associated Kaposi's sarcoma (KS) in three patients. Directly and up to 50 min after intravenous administration of ICG (2-4 mg kg(-1) body weight), KS (n=57), mainly plaque-type, were irradiated using a diode laser (lambda em=805 nm, 100 J cm[-2], 0.5-5 W cm[-2]) matching the absorption maximum. Complete remission of KS (n=16) was achieved when irradiated 1-30 min after injection of the second dose of ICG (2 x 2 mg kg(-1) b.w., 30 min apart) with 3-5 W cm(-2) and 100 J cm(-2). Biopsies (n=3) revealed necrosis of the tumour 24 h and complete remission 4 weeks after therapy. In general, systemic side-effects were not observed and cosmetic results were very good. However, hyperpigmentation occurred temporarily in lesions located on the lower extremities. These findings show that AIDS-associated KS can be effectively treated after photosensitization with ICG and subsequent irradiation with an appropriate diode laser. However, additional investigations need to elucidate the exact mechanism of action of ICG-mediated...Continue Reading

Citations

Sep 27, 2001·Lasers in Surgery and Medicine·M SatoK Fujikawa
Jan 22, 2002·Journal of Clinical Laser Medicine & Surgery
Aug 8, 2002·Journal of Clinical Laser Medicine & Surgery
Mar 10, 2011·Nanomedicine·Liraz Larush, Shlomo Magdassi
Apr 13, 2011·International Journal of Cancer. Journal International Du Cancer·Gal ShafirsteinRobert J Griffin
Jul 3, 2016·International Journal of Dermatology·Hyun-Min SeoWon-Serk Kim
Nov 14, 2001·American Journal of Clinical Dermatology·S KarrerM Landthaler
Jan 1, 2008·Journal of Biomedical Optics·Mohammad A YaseenBahman Anvari
Jun 8, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·W BäumlerG Shafirstein
Dec 17, 2003·Lasers in Surgery and Medicine·Valery V TuchinGregory B Altshuler
Feb 7, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Philipp P CaffierBenedikt Sedlmaier
May 12, 2012·International Journal of Biomedical Imaging·Jarmo T AlanderPetri Välisuo
Aug 20, 2016·Optica·Yu-Cheng ChenXudong Fan
Sep 1, 2006·Photomedicine and Laser Surgery·Anderson J GomesAntonio C Tedesco
Jul 22, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sonani MindtKai Nowak
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Beatriz Fernández-JorgeEduardo Fonseca
Jan 22, 2003·Intensive Care Medicine·Bendicht P WagnerJuerg Pfenninger
Jul 6, 2000·Journal of Photochemistry and Photobiology. B, Biology·E DelaeyP de Witte
Jul 22, 2008·Journal of the American Academy of Dermatology·Robert A SchwartzLaura Scuderi

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