Indocyanine green clearance after cardiac surgery: the impact of cardiopulmonary bypass

Perfusion
P MöhnleF Weis

Abstract

Plasma clearance of indocyanine green has recently been established as a tool to monitor hepatic function and perfusion non-invasively. Reduced indocyanine green clearance has been associated with adverse outcome in cardiac surgery patients, and cardiopulmonary bypass has been hypothesized to be one important triggering factor. We performed a prospective observational study comparing the influence of off-pump and on-pump coronary surgery on perioperative indocyanine green clearance. Twenty-five consecutive adult patients without known pre-existing hepatic diseases scheduled for off-pump coronary artery bypass grafting were evaluated for hepatic dysfunction pre- and postoperatively with serial measurements of indocyanine green plasma clearance, specific laboratory values and liver function scores. Twenty-five matched patients who underwent coronary artery bypass grafting surgery with cardiopulmonary bypass in the same period served as controls. Parameters of postoperative hepatic function, including measurements of indocyanine green plasma clearance and specific laboratory values and scores, did not differ significantly between patients undergoing off-pump coronary artery bypass grafting and patients undergoing coronary artery b...Continue Reading

References

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Citations

Dec 18, 2013·Journal of Critical Care·Florian WeisPatrick Möhnle
Apr 30, 2020·Current Opinion in Critical Care·Matthias NoitzMartin W Dünser
Mar 29, 2018·Interactive Cardiovascular and Thoracic Surgery·Joaquín Fernández-DoblasRaúl F Abella
Jan 5, 2017·Biotechnology Letters·Chunlong SunMin Ji

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Methods Mentioned

BETA
coronary artery bypass
coronary

Software Mentioned

PASW Statistics
SPSS

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