Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography

Journal of Biomedical Optics
Chen XuQuing Zhu

Abstract

To overcome the intensive light scattering in biological tissue, diffuse optical tomography (DOT) in the near-infrared range for breast lesion detection is usually combined with other imaging modalities, such as ultrasound, x-ray, and magnetic resonance imaging, to provide guidance. However, these guiding imaging modalities may depend on different contrast mechanisms compared to the optical contrast in the DOT. As a result, they cannot provide reliable guidance for DOT because some lesions may not be detectable by a nonoptical modality but may have a high optical contrast. An imaging modality that relies on optical contrast to provide guidance is desirable for DOT. We present a system that combines a frequency-domain DOT and real-time photoacoustic tomography (PAT) systems to detect and characterize deeply seated targets embedded in a turbid medium. To further improve the contrast, the exogenous contrast agent, indocyanine green (ICG), is used. Our experimental results show that the combined system can detect a tumor-mimicking phantom, which is immersed in intralipid solution with the concentrations ranging from 100 to 10 μM and with the dimensions of 0.8 cm × 0.8 cm × 0.6 cm, up to 2.5 cm in depth. Mice experiments also confir...Continue Reading

Citations

Dec 3, 2014·The Journal of Surgical Research·Charles W KimbroughLacey R McNally
Jan 24, 2017·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Ryan K W CheeRoger J Zemp
May 3, 2015·Ultrasonic Imaging·Junjie YaoLihong V Wang
Feb 3, 2018·Journal of Medical Imaging·Michael A PinkertKevin W Eliceiri
Nov 22, 2016·Biomedical Optics Express·Valeriya PerekatovaIlya Turchin
Apr 2, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Steve S ChoJohn Y K Lee
Jul 24, 2015·Biomedical Optics Express·Julia MärkJan Laufer
Dec 19, 2020·Molecular Imaging·Mucong LiJunjie Yao
May 28, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Chao ZhangSanjiv Sam Gambhir

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.