Indocyanine green fluorescence method for sentinel lymph node biopsy in breast cancer

Asian Journal of Surgery
Joseph LinYu-Jun Chang

Abstract

Breast biopsy and analysis of sentinel lymph nodes (SLNs) accurately predict tumor status in the affected basin and help in avoiding unnecessary axillary lymph node dissection, which is associated with remarkable morbidity risk. Blue dye and radioisotope are the most widely used mapping agents, but non-radioactive tracers of comparable accuracy warrant further investigation. This study aimed to investigate utilization of indocyanine green (ICG) fluorescence in sentinel node localization compared with blue dye and to assess the incremental value of ICG. A total of 39 consecutive patients underwent sentinel lymph node biopsy (SLNB) (40 cases: 38 unilateral and 1 bilateral) with combined blue dye and ICG for localization. The obtained fluorescence images of the lymphatic system were investigated. All 84 lymph nodes removed in 40 procedures were identified by ICG, but only 37 were identified by blue dye. The ICG method identified an average of 2.1 SLNs in 39 of 40 cases with a detection rate of 97.5%, but only 0.93 SLN per case with blue dye. Subcutaneous lymphatic channel patterns were also detected by fluorescent imaging in 37 procedures, which all revealed lymphatic drainage toward the axilla except in one case with internal mam...Continue Reading

Citations

Dec 17, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Cemil YükselLütfi Doğan
Jul 3, 2021·International Journal of Molecular Sciences·Banendu Sunder DashJyh-Ping Chen
Oct 12, 2021·European Journal of Nuclear Medicine and Molecular Imaging·H M SchouwS Kruijff

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