Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging

Biomaterials
Cuifang ZhengLintao Cai

Abstract

Indocyanine green (ICG) is a near-infrared (NIR) fluorescence dye for extensive biological application, but limited by its poor aqueous stability in vitro, concentration-dependent aggregation, rapid elimination from the body, and lack of target specificity. In this paper, to overcome these limitations, folate receptor-targeted, ICG dye-doped poly(d,l-lactide-co-glycolide) (PLGA) lipid nanoparticles (FA-ICG-PLGA-lipid NPs) were constructed by a single-step self-assemble and nanoprecipitation method. The prepared FA-ICG-PLGA-lipid NPs exhibited good biocompatibility, monodispersity, excellent NIR penetration ability, significant stability against photobleaching and long circulation time. The intracellular uptake experiment proved the targeting efficacy of the FA-ICG-PLGA-lipid NPs was more effective in folate receptor over-expressing MCF-7 cells than folate receptor negative A549 cells. Furthermore, the in vivo experiments showed the FA-ICG-PLGA-lipid NPs were specifically targeted to the tumor, and its circulation time was much longer than free ICG. These biocompatible and biodegradable NIR-NPs prove a potential application in tumor diagnosis and targeted imaging due to its high aqueous stability, excellent NIR optical properties...Continue Reading

References

Jan 1, 1978·Physics in Medicine and Biology·R C Benson, H A Kues
Jan 26, 2002·Journal of Photochemistry and Photobiology. B, Biology·J M MaarekJ Harimoto
Nov 5, 2002·Current Opinion in Chemical Biology·Eva M Sevick-MuracaMichael Gurfinkel
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
Jul 26, 2003·Journal of Biomedical Optics·Joanna MalickaJoseph R Lakowicz
Oct 29, 2003·Current Opinion in Chemical Biology·John V Frangioni
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sun Hwa KimTae Gwan Park
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas C StoverMark Kester
Dec 30, 2008·Biomaterials·Juliana M ChanOmid C Farokhzad
Apr 16, 2009·Nano Letters·D W Boukhvalov, M I Katsnelson
May 19, 2009·Current Opinion in Chemical Biology·Markus Rudin

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Citations

Mar 22, 2014·International Journal of Nanomedicine·Xiaomin YiJianlin Yuan
Nov 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hyung Ki YoonRaoul Kopelman
May 29, 2015·Contrast Media & Molecular Imaging·Susana P EgusquiaguirreManuela Igartua
Mar 21, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Emma PortnoySara Eyal
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Benjamin NotteletJean Coudane
Aug 26, 2014·Chemistry : a European Journal·Graeme T SpenceBradley D Smith
Aug 16, 2014·Advanced Materials·Peng HuangXiaoyuan Chen
Sep 24, 2015·ACS Applied Materials & Interfaces·Lijia JingJie Tian
Jun 26, 2015·Photochemistry and Photobiology·Nayan J PatelRavindra K Pandey
Jan 28, 2014·Biomaterials·Jia YuXianfeng Chen
Nov 28, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eliézer JägerKarel Ulbrich
Aug 24, 2013·Biotechnology Advances·Francesco CanfarottaSergey A Piletsky
Oct 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shanthi GaneshMansoor M Amiji
Oct 9, 2013·Chemical Society Reviews·Koen RaemdonckStefaan C De Smedt
Apr 21, 2016·Molecular Pharmaceutics·Tatu LajunenArto Urtti
Feb 6, 2017·ACS Applied Materials & Interfaces·Hwan-Jun YoonJi-Ho Park
Feb 6, 2018·Chemistry, an Asian Journal·Xueyang FangTianfeng Chen

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