PMID: 6791164Jun 1, 1981Paper

Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters

Proceedings of the National Academy of Sciences of the United States of America
H FujikiR E Moore

Abstract

Dihydroteleocidin B, which is a derivative of teleocidin from Streptomyces, showed potent tumor-promoting activity in vivo when painted on mouse skin. Although the chemical structure of dihydroteleocidin B is entirely different from those of phorbol esters, the tumor-promoting activity of dihydroteleocidin B was found to be comparable to that of 12-O-tetradecanoylphorbol 13-acetate (TPA) in vivo. Teleocidin from Streptomyces and lyngbyatoxin A and debromoaplysiatoxin from the marine blue-green alga Lyngbya majuscula induced ornithine decarboxylase activity when painted on mouse skin, their effects being similar to those of dihyroteleocidin B and TPA. 13-cis-Retinoic acid inhibited this ornithine decarboxylase induction when painted on the skin 1 hr before these natural products. These three compounds produced adhesion of human promyelocytic leukemia cells (HL-60) to the flasks and inhibited differentiation of Friend erythroleukemia cells induced by dimethyl sulfoxide. The in vitro biological potencies of teleocidin and lyngbyatoxin A were almost as great as those of dihydroteleocidin B and TPA, but that of debromoaplysiatoxin was much weaker.

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Citations

Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·H FujikiT Sugimura
Sep 1, 1990·Environmental Geochemistry and Health·A Kwiatkowski
Nov 30, 1983·Biochemical and Biophysical Research Communications·S YamamotoR Kato
Jul 1, 1996·Toxicon : Official Journal of the International Society on Toxinology·H NagaiY Hokama
Jan 1, 1992·Pharmacology & Therapeutics·J DiGiovanni
Feb 1, 1995·Mutation Research·S D DertingerA M Tometsko
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L C OsborneE P Larkin
Feb 1, 2002·Toxicon : Official Journal of the International Society on Toxinology·Emiko ItoTakeshi Yasumoto
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Sep 25, 1999·Bioorganic & Medicinal Chemistry Letters·Y EndoA Itai
Jan 15, 2000·Bioorganic & Medicinal Chemistry Letters·Y Endo, A Yokoyama
Jul 13, 2013·The Journal of Organic Chemistry·Michele MariGiovanni Piersanti
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B FriedmanM R Rosner
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E RozengurtJ Sinnett-Smith
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A ItaiS Sakai
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SuganumaT Sugimura
Apr 1, 1983·Environmental Health Perspectives·H FujikiR E Moore
Aug 1, 1986·Environmental Health Perspectives·T Sugimura
May 16, 2014·Marine Drugs·Weina JiangHiroshi Nagai
Jun 13, 2013·Journal of Cancer Research and Clinical Oncology·Hirota FujikiMasami Suganuma
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Dec 5, 2015·Frontiers in Microbiology·Rajesh P RastogiAran Incharoensakdi
Mar 10, 2016·Chemical Research in Toxicology·Luis M Botana
Mar 16, 1983·Biochemical and Biophysical Research Communications·M Wilkinson, A Morris
Nov 30, 1982·Biochemical and Biophysical Research Communications·T WatanabeT Sugimura
Aug 15, 1989·Biochemical and Biophysical Research Communications·J Heikkilä, K E Akerman

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