Abstract
Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix degradation. Despite considerable progress in identifying targets involved in these processes, therapeutic approaches aiming to reduce aneurysm growth and rupture are still scarce. Indoleamine 2-3 dioxygenase 1 (IDO) is the first and rate-limiting enzyme involved in the conversion of tryptophan (Trp) into kynurenine (Kyn) pathway. In this study, we investigated the role of IDO in two different models of AAA in mice. Mice with deficiencies in both low density receptor-deficient (Ldlr-/-) and IDO (Ldlr-/-Ido1-/-) were generated by cross-breeding Ido1-/- mice with Ldlr-/-mice. To induce aneurysm, these mice were infused with angiotensin II (Ang II) (1000 ng/min/kg) and fed with high fat diet (HFD) during 28 days. AAAs were present in almost all Ldlr-/- infused with AngII, but only in 50% of Ldlr-/-Ido1-/- mice. Immunohistochemistry at an early time point (day 7) revealed no changes in macrophage and T lymphocyte infiltration within the vessel wall, but showed reduced apoptosis, as assessed by TUNEL assay, and increased α-actin staining within the media of Ld...Continue Reading
References
Nov 18, 1996·Annals of the New York Academy of Sciences·R W Thompson, W C Parks
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael W ManningAlan Daugherty
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan Daugherty, Lisa A Cassis
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
May 9, 2006·Journal of Vascular Surgery·Sarah J Van Vickle-ChavezRobert W Thompson
Jan 25, 2007·JAMA : the Journal of the American Medical Association·David B HellmannJulie A Freischlag
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A CassisAlan Daugherty
Mar 2, 2010·Nature Medicine·Yutang WangRoland Stocker
Nov 17, 2010·Nature Reviews. Cardiology·Ian M NordonMatt M Thompson
Dec 25, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Eva Ringdal PedersenOttar Nygård
Jul 26, 2012·Surgery·Castigliano M BhamidipatiGorav Ailawadi
Aug 3, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Hafid Ait-OufellaZiad Mallat
Nov 28, 2013·Circulation Research·Qiongxin WangMing-Hui Zou
Apr 18, 2015·International Journal of Cardiology·Simone J P M EussenGrethe S Tell
Aug 4, 2015·Cell Metabolism·Sarvenaz MetghalchiZiad Mallat
Oct 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jennifer E ColeClaudia Monaco
May 26, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong Lu, Alan Daugherty
Oct 6, 2017·Circulation·Qiongxin WangMing-Hui Zou
Citations
Mar 9, 2019·Cardiovascular Research·Daniel F J Ketelhuth
Jan 9, 2019·Frontiers in Immunology·Camille Martin-GallausiauxNicolas Lapaque
Sep 26, 2019·Frontiers in Immunology·Soraya Taleb
Nov 30, 2019·Frontiers in Immunology·Fanni A Boros, László Vécsei
Dec 5, 2020·Circulation·Nada Joe MelhemSoraya Taleb
Dec 11, 2020·Journal of Atherosclerosis and Thrombosis·Masanori NishimuraYujiro Asada
Feb 19, 2021·Journal of Vascular Surgery·Baohui XuRonald L Dalman
Feb 23, 2021·Frontiers in Cardiovascular Medicine·Yangfeng HouJing Wang
Jul 10, 2021·Free Radical Biology & Medicine·Yunjia LiLei Gao
Sep 2, 2021·Scientific Reports·Smriti Murali KrishnaJonathan Golledge
Sep 10, 2021·Cell Biology International·Fahimeh HeidariNasrollah Erfani