Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool.

Frontiers in Immunology
Martina MandaranoAngelo Sidoni

Abstract

Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well-elucidated. IDO2 overexpression was documented in some human tumors, but the linkage between IDO2 expression and cancer progression is still unclear, in particular in non-small cell lung cancer (NSCLC). Immunohistochemical expression and cellular localization of IDO2 was evaluated on 191 formalin-fixed and paraffin-embedded resected NSCLC. Correlations between IDO2 expression, clinical-pathological data, tumor-infiltrating lymphocytes (TILs), immunosuppressive tumor molecules (IDO1 and programmed cell death ligand-1 - PD-L1 -) and patients' prognosis were evaluated. IDO2 high expression is strictly related to high PD-L1 level among squamous cell carcinomas group (p = 0.012), to either intratumoral or mixed localization of TILs (p < 0.001) and to adenocarcinoma histotype (p < 0.001). Furthermore, a significant correlation between IDO2 high expression and poor non-small cell lung cancer prognosis was detected (p = 0.011). The current study reaches interesting knowledge about IDO2 in non-small cell lung c...Continue Reading

References

Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Aug 19, 2007·Cancer Biology & Therapy·Vaios KaranikasAnastasios E Germenis
Feb 20, 2008·The International Journal of Biochemistry & Cell Biology·Helen J BallNicholas H Hunt
Apr 18, 2008·Cancer Immunology, Immunotherapy : CII·Stefan LöbPeter Terness
May 7, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hajime J YuasaNicholas H Hunt
May 30, 2009·Journal of the American College of Surgeons·Agnieszka K WitkiewiczJonathan R Brody
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Jan 10, 2014·International Immunology·Richard MetzGeorge C Prendergast
Nov 27, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jin Won KimKeun-Wook Lee
Dec 6, 2014·Frontiers in Immunology·George C PrendergastLaura Mandik-Nayak
Jan 30, 2015·Frontiers in Immunology·Michael PlattenKatharina Ochs
Feb 16, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A WangG T Liu
Feb 19, 2015·Frontiers in Immunology·Nicolas van Baren, Benoît J Van den Eynde
Feb 3, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elisabeth BrambillaMing Sound Tsao
Feb 4, 2016·Trends in Immunology·David H Munn, Andrew L Mellor
Feb 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ching-Yao YangPan-Chyr Yang
May 7, 2016·Science·Christian U BlankTon N Schumacher
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren M F MerloLaura Mandik-Nayak
Jul 22, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurt A SchalperDavid L Rimm
Nov 29, 2016·Clinical Medicine Insights. Pathology·Lauren M F Merlo, Laura Mandik-Nayak
Feb 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M-S TsaoE Brambilla
Mar 23, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lieve BrochezVibeke Kruse
May 30, 2017·Current Opinion in Pharmacology·Giada MondanelliVincenzo Bronte
Jul 8, 2017·Archives of Pathology & Laboratory Medicine·Erik ThunnissenYasushi Yatabe
Oct 21, 2017·International Journal of Tryptophan Research : IJTR·Felicita F JusofHelen J Ball
Feb 8, 2018·International Review of Cell and Molecular Biology·George C PrendergastAlexander J Muller
Mar 13, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Edwin Roger ParraIgnacio I Wistuba
Jul 18, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yuka KozumaYoshihiko Maehara
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Stefan ZimmermannShirish M Gadgeel

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Feb 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pengcheng LiJia Song
May 11, 2021·Frontiers in Immunology·Giada MondanelliClaudia Volpi
Jun 20, 2021·The FEBS Journal·Maria Teresa PallottaUrsula Grohmann

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