Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality

Mechanisms of Ageing and Development
M PertovaaraM Hurme

Abstract

Indoleamine 2,3-dioxygenase (IDO), an enzyme degrading tryptophan (trp) to kynurenine (kyn), suppresses T cell activity. Ageing of the immune system, immunosenescence, includes a decline in T cell function. We therefore sought to establish whether IDO activity is involved in immunosenescence and whether it predicts mortality in aged subjects. We measured kyn/trp, reflecting IDO activity, in 284 nonagenarians and 309 blood donor controls. IDO activity was significantly higher in nonagenarians compared with controls and IDO activity at study entry predicted subsequent mortality in nonagenarians. Thus, increased IDO activity might be a mechanism involved in the decline of T cell responses in immunosenescence.

References

May 21, 1999·The American Journal of Medicine·T B HarrisR Wallace
Apr 17, 2001·Current Opinion in Hematology·H BruunsgaardB K Pedersen
Aug 2, 2003·Aging Clinical and Experimental Research·Sirkka GoebelerAntti Hervonen
Jan 25, 2005·Mechanisms of Ageing and Development·M HurmeA Hervonen
May 11, 2005·Immunological Reviews·Graham PawelecAnders Wikby
May 13, 2005·Mechanisms of Ageing and Development·Mikko HurmeTerho Lehtimäki

❮ Previous
Next ❯

Citations

Feb 10, 2009·Cancer Immunology, Immunotherapy : CII·Mauro Provinciali
Jun 23, 2011·Journal of Neural Transmission·Trevor W StoneL Gail Darlington
Apr 9, 2013·Trends in Molecular Medicine·Annemieke T van der Goot, Ellen A A Nollen
Nov 26, 2009·The British Journal of Nutrition·Lucile CapuronSophie Layé
Feb 18, 2011·Journal of Neuroinflammation·Allison B GoldKrista L Lanctôt
Dec 19, 2013·PloS One·Birgit WeinbergerBeatrix Grubeck-Loebenstein
Jun 16, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Kenneth W HanceJohn W Greiner
Jan 15, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ximing MoAiguo Tang
Jul 16, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·P NiinisaloM Hurme
Apr 18, 2015·International Journal of Cardiology·Simone J P M EussenGrethe S Tell
Jun 23, 2009·Psychoneuroendocrinology·Walter SwardfagerKrista L Lanctôt
Sep 26, 2007·The European Journal of Neuroscience·L G DarlingtonT W Stone
Jan 18, 2012·The FEBS Journal·Trevor W StoneL Gail Darlington
May 8, 2013·British Journal of Pharmacology·Trevor W Stone, L Gail Darlington
Aug 9, 2011·Journal of Neurochemistry·Caroline M ForrestTrevor W Stone
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug
Sep 18, 2012·Clinical Lymphoma, Myeloma & Leukemia·Vesa LindströmMarjatta Sinisalo
Aug 6, 2016·Neuroscience Letters·Erik LadomerskyDerek A Wainwright
Oct 27, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yiyi ZhangAlan Cheng
Oct 16, 2015·Lancet Neurology·Jeffrey B CarrollSarah J Tabrizi
Jul 21, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mona El RefaeyCarlos M Isales
Feb 1, 2011·Cellular & Molecular Immunology·Carlo SelmiM Eric Gershwin
Feb 17, 2018·International Journal of Cancer. Journal International Du Cancer·Xiaoyan LiuZhigang Ji
Feb 15, 2019·Nature Reviews. Drug Discovery·Michael PlattenChristiane A Opitz
Jul 7, 2019·Analytical and Bioanalytical Chemistry·Yitao LiTianlu Chen
Jan 30, 2020·Proteomics·Peter Yuli XingParag Kundu
Nov 19, 2019·Oxidative Medicine and Cellular Longevity·Helen KaiserMark W Hamrick
Oct 17, 2017·Cellular and Molecular Life Sciences : CMLS·Aurelia SantoroClaudio Franceschi
May 21, 2019·Investigative Ophthalmology & Visual Science·Douglas A JabsPeter W Hunt
Jul 3, 2020·Frontiers in Immunology·Lijie ZhaiDerek A Wainwright
Feb 3, 2018·Aging and Disease·Barbara StrasserMartin Burtscher
Dec 26, 2018·Oxidative Medicine and Cellular Longevity·L A Ramos-ChávezV Pérez de la Cruz
Mar 14, 2019·International Journal of Environmental Research and Public Health·Małgorzata SzkupElżbieta Grochans
Nov 19, 2019·Frontiers in Immunology·Freek J H SorgdragerPeter P De Deyn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.