Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation

Bone Marrow Transplantation
S PanigrahiM Y Shapira

Abstract

Fungal arthritis and osteomyelitis are rare and documented mainly in immunocompromised or neutropenic patients. Patients receiving therapeutic immunosuppression for organ transplants have also reported to suffer from aspergillus osteoarthritis. We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation. Both were suffering from acute and chronic GVHD and treated with heavy immunosuppression including steroids and cyclosporine. Interestingly in one of our patients, the arthritis was almost asymptomatic and did not spread to other organs. Heavy pre- and post-transplant immunosuppression is a major risk factor for invasive fungal infection, which can involve remote organs and manifest in an indolent and atypical manner.

References

May 1, 1991·British Journal of Haematology·P BordigoniD Sommelet
Feb 4, 1998·British Journal of Rheumatology·S SteinfeldT Appelboom
Oct 3, 1998·Annals of Internal Medicine·E J AnaissieM J Keating
Jun 17, 1999·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J R Wingard
Dec 22, 1999·Annals of Hematology·E GunsiliusA L Petzer

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Citations

Nov 22, 2005·Infectious Disease Clinics of North America·Rakhi Kohli, Susan Hadley
Jun 16, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P R KumashiD P Kontoyiannis
Sep 10, 2016·Medical Mycology·Maria N GamaletsouUNKNOWN International Osteoarticular Mycoses Consortium

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