Indomethacin--short-term therapy vs. single low dosage radiation for prevention of periarticular ossifications after total hip endoprosthesis

Zeitschrift für Orthopädie und ihre Grenzgebiete
R Bremen-KühneC Franke

Abstract

With a general incidence of about 40% periarticular ossifications (PAO) constitute one of the more frequent complications after total hip arthroplasty. A prospective, randomized therapy--study investigates the prophylactic values of Indomethacin-Short-Term-Therapy and Single-Dose-Radiatio, respectively. Consecutive patients for elective, cementless THA were randomized; the Indomethacin-Group (A, n = 31 at the end of the study) was admitted 100 mg Indomethacin/supp. at the day of operation and 3 x 25 mg orally from postoperative day 1 to 10. Other NSAID were not given. The Radiatio-group (B; n = 19) was irradiated by a single dose of 6 Gy within postoperative days 1 to 4; no NSAID were admitted. Follow up was at dismissal and after 6 (NU 1) and 12 (NU 2) months. Incidence and severity of PAO and the clinical objective and subjective results were registered. Age- and side-distribution as well as the etiologies were comparable in both groups. All patients took part in NU 1 and 90% in NU 2. There were no major differences in the incidence of postoperative PAO in both groups. In 68% (A) and 53% (B), resp., there were no PAO at dismissal and after six months, PAO of Brooker Grade I and II were seen in 30 (A) and 47% (B), resp., PAO o...Continue Reading

Citations

Feb 19, 2011·Archives of Orthopaedic and Trauma Surgery·Patrick Vavken, Ronald Dorotka
Mar 10, 2015·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Troy J BoffeliJonathan C Thompson
Feb 29, 2016·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Troy J BoffeliKevin J Mahoney
May 26, 2012·The Open Orthopaedics Journal·Tilman PfitznerGeorg Matziolis
Apr 28, 2007·The Journal of Bone and Joint Surgery. British Volume·T N BoardM L Porter
Jun 12, 2009·Clinical Orthopaedics and Related Research·Patrick VavkenThomas P Sculco
Mar 29, 2003·Archives of Orthopaedic and Trauma Surgery·Robert LegensteinAlfred Ungersböck

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