PMID: 6196763Jul 1, 1983Paper

Indomethacin alters the effects of substance-P and VIP on isolated airway smooth muscle

Peptides
J F Regal, D E Johnson

Abstract

Both substance-P and vasoactive intestinal peptide (VIP) have previously been demonstrated to contract and relax, respectively, the isolated guinea pig trachea. In addition, substance-P and VIP have been localized within the pulmonary innervation of various species. In the present studies, substance-P was found to cause a concentration-related contraction of isolated lung parenchymal strips of the guinea pig, as well as isolated tracheal strips. VIP caused a significant concentration-related relaxation of the isolated tracheal strip, but not the lung parenchymal strip. Indomethacin, a prostaglandin synthetase inhibitor, potentiated the contractile response of the trachea to substance-P and inhibited the VIP- and isoproterenol-induced relaxation. These studies are potentially important in understanding the pathogenesis of bronchospastic disorders, since alterations in prostaglandin biosynthesis may result in hyperreactivity of airways to contractile agonists such as neurotransmitters, as well as an inhibition of relaxation induced by endogenous substances such as VIP or beta agonists.

References

Jun 1, 1978·The Journal of Clinical Investigation·J M Drazen, M W Schneider
Jan 1, 1974·Annals of the New York Academy of Sciences·S I SaidL D Holden
Jan 1, 1982·Pharmacology·R Couture, D Regoli
Jun 19, 1981·European Journal of Pharmacology·C OminiF Berti
Jan 1, 1983·International Journal of Immunopharmacology·J F Regal, R J Pickering
Jan 1, 1982·Annals of the New York Academy of Sciences·S I Said

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Citations

Feb 26, 1985·European Journal of Pharmacology·P Schoeffter, J C Stoclet
Jan 21, 1992·European Journal of Pharmacology·E J KusnerR D Krell
Jun 17, 1992·European Journal of Pharmacology·M T-BenchekrounA Cadieux
May 30, 1995·Regulatory Peptides·C R Killingsworth, S A Shore
Apr 3, 2002·Mediators of Inflammation·Apostolia A HatziefthimiouPaschalis-Adam Molyvdas
Dec 1, 1987·The American Review of Respiratory Disease·S I Said
Jun 1, 1987·The Journal of Clinical Investigation·N P Stimler-Gerard

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