PMID: 3881647Feb 1, 1985Paper

Indomethacin and salicylate decrease epinephrine-induced glycogenolysis

Metabolism: Clinical and Experimental
J D MillerM A Sperling


Epinephrine (E) produces an immediate (0-30 minutes) rise in hepatic glucose production (Ra), largely due to activation of glycogenolysis; thereafter, E-stimulated gluconeogenesis becomes the major factor maintaining glucose production. To investigate the possible role of arachidonic acid metabolites on Ra during E stimulation, we infused E in trained conscious dogs before and during administration of two inhibitors of arachidonic acid metabolism, indomethacin (INDO) and salicylate (S). On separate days, experimental animals were treated with both oral and IV INDO and oral acetylsalicylic acid and IV sodium salicylate. Ra and glucose utilization (Rd), both in mg x kg-1 min-1, were calculated by isotope dilution using 3-3H-glucose. After achieving steady state specific activity, control (C) and experimental animals (n = 6 per group) received E (0.1 ug x kg-1 min-1) for 150 minutes, raising plasma levels to approximately 1500 pg/mL in each group. In C, plasma glucose (G; mg/dL) rose by 17 +/- 5 at 10 minutes and 19 +/- 3 at 20 minutes due to an initial spike in Ra (2.7 +/- 0.2 to 4.9 +/- 0.5; P less than 0.01) at 10 minutes. INDO and S treatment attenuated this initial (10-20 minutes) rise in G (P less than 0.05) due to a lower s...Continue Reading


Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M I SiegelP Cuatrecasas
Sep 1, 1977·The Journal of Clinical Investigation·R P Robertson, M Chen
Dec 1, 1975·The American Journal of Physiology·N AltszulerR Steele
Feb 1, 1976·Metabolism: Clinical and Experimental·L Saccà, G Perez
Jan 1, 1972·Metabolism: Clinical and Experimental·B Issekutz, M Allen
Sep 1, 1972·Endocrinology·P SherlineW H Glinsmann
Sep 15, 1973·Biochemical Pharmacology·V DinnendahlP S Schönhöfer
Nov 1, 1972·Biochemical and Biophysical Research Communications·M Hamberg
Jul 15, 1973·Biochemical Pharmacology·P J Lefebvre, A S Luyckx
Sep 1, 1984·Metabolism: Clinical and Experimental·S GanguliW J Banach
Sep 11, 1980·Nature·S A Goueli, K Ahmed
Apr 1, 1982·Archives of Biochemistry and Biophysics·S Hammarström
Apr 1, 1983·Physiological Reviews·G HetenyiM Vranic
May 1, 1980·Diabetes·E Topol, R G Brodows
Apr 1, 1980·The Journal of Clinical Endocrinology and Metabolism·L SaccàB Ungaro
May 1, 1980·The Journal of Clinical Endocrinology and Metabolism·U Lilavivathana, R G Brodows
Jul 1, 1981·The Medical Clinics of North America·R P Robertson
Feb 1, 1982·The Journal of Clinical Investigation·L SaccàR S Sherwin
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·W P Newman, R G Brodows
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE

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