PMID: 8594951Dec 1, 1995Paper

Indomethacin blocks the febrile response induced by interleukin-8 in rabbits

The American Journal of Physiology
A R ZampronioGlória E P Souza

Abstract

Interleukin (IL)-8 induces fever in rats by a mechanism independent of the release of cyclooxygenase products. The purpose of this study was to investigate whether a similar mechanism is responsible for the pyrogenic effect of IL-8 in rabbits. Intravenous (0.31-5.0 ng/kg) or intracerebroventricular (15.6-250 pg) injections of IL-8 induced a dose-dependent increase in body temperature. The correlations between the doses of recombinant human IL-8 and the fever index were 0.98 and 0.99 for the intravenous and intracerebroventricular injections, respectively. The pyrogenic activity of IL-8 was not due to contamination with lipopolysaccharide (LPS), inasmuch as the Limulus amoebocyte lysate test showed < 10 pg endotoxin/micrograms IL-8, and boiled IL-8 lost its pyrogenic activity. Indomethacin (2 and 5 mg/kg i.p.) abolished the febrile response induced by the intravenous injection of LPS (5.0 ng/kg), IL-1 beta (5 ng/kg), and IL-8 (5 ng/kg). Indomethacin also abolished the fever induced by the intracerebroventricular injection of IL-8 (62.5 pg) but only partially reduced the response induced by the injection of IL-1 beta (25 pg icv). These results show that, different from rats, indomethacin blocks the febrile response induced by the...Continue Reading

Citations

May 8, 2000·Journal of Applied Physiology·A A Steiner, L G Branco
Jul 23, 2002·Journal of Applied Physiology·K C BicegoL G S Branco
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kazuhiro Nakamura

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