Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine

Naunyn-Schmiedeberg's Archives of Pharmacology
Claudia CzyborraMartin C Michel

Abstract

The sphingomyelin breakdown products sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) constrict intrarenal microvessels in vitro in a pertussis toxin (PTX) sensitive manner, and S1P also reduces renal blood flow in vivo. Nevertheless, both S1P and SPC have been reported to enhance diuresis and natriuresis. This pattern is similar to that of neuropeptide Y, which also reduces renal blood flow and enhances diuresis and natriuresis. The latter effects are inhibited by the cyclooxygenase inhibitor indomethacin, and various S1P and SPC responses have also been linked to the cyclooxygenase pathway. Therefore, we have investigated whether indomethacin can alter the renal effects of S1P and SPC in anaesthetised rats in vivo. In line with earlier experiments S1P bolus injections dose-dependently reduced renal blood flow (by up to 4.8 +/- 0.5 ml min(-1)), and this was not significantly affected by indomethacin treatment (5 mg kg(-1) i.p.). Infusion of S1P but not of SPC (30 microg kg(-1) min(-1) each) for 60 min reduced renal blood flow by up to 0.8 +/- 0.2 ml min(-1), and this was not markedly altered by indomethacin. Despite the differential renovascular effect, both S1P and SPC enhanced diuresis by up to 215 +/- 65 ...Continue Reading

References

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Citations

Mar 30, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Denise G Hemmings
Jun 17, 2008·Pharmacological Reviews·Kazuaki TakabeSarah Spiegel
Apr 12, 2011·American Journal of Physiology. Renal Physiology·Qing ZhuNingjun Li
Jul 28, 2013·Critical Reviews in Clinical Laboratory Sciences·Emmanuel E EgomMamas A Mamas
Mar 30, 2007·Acta Paediatrica. Supplement·Martin C MichelStephan L M Peters
Nov 7, 2019·Cancers·Mi Kyung Park, Chang Hoon Lee
Sep 29, 2019·Journal of the American Society of Nephrology : JASN·Theun de GrootRon Korstanje
Aug 8, 2019·American Journal of Physiology. Renal Physiology·Suttira Intapad
Aug 6, 2021·Prostaglandins & Other Lipid Mediators·Jihua TianYun Zhou

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