Indomethacin disposition and indomethacin-induced platelet dysfunction in premature infants

Journal of Clinical Pharmacology
Z FriedmanE S Vesell

Abstract

Indomethacin failed to produce permanent ductal closure in any of four premature infants with patent ductus arteriosus to whom the drug was given. Indomethacin half-lives measured in two premature infants were 21 and 24 hours, respectively, much longer than in full-term newborns or adults. Platelet function, as measured by platelet aggregation, was grossly abnormal for two to four days after indomethacin administration, normal values returning only by the ninth and tenth days. Gastrointestinal bleeding and transient renal dysfunction occurred in one infant. Measurement of plasma indomethacin concentrations in sick, low-birthweight infants could help guide indomethacin dose and dosage interval, prevent drug accumulation, and reduce toxicity. Further studies of potential toxicity seem to be indicated before instituting widespread indomethacin administration for ductal closure in premature infants.

References

Jan 18, 1975·Lancet·R B ElliottJ M Neutze
Aug 30, 1975·Lancet·N C Christensen, J Fabricus
Mar 1, 1977·The Journal of Pediatrics·Z FriedmanJ A Oates
Feb 1, 1977·Hospital Practice·A M Rudolph, M A Heymann
Sep 2, 1976·The New England Journal of Medicine·W F FriedmanS E Kirkpatrick
Feb 1, 1977·The Journal of Pediatrics·W F FriedmanA M Rudolph
Sep 2, 1976·The New England Journal of Medicine·M A HeymannN H Silverman
Aug 1, 1975·The Journal of Pediatrics·J P GuignardE Gautier
Feb 13, 1974·Journal of Chromatography·D G FerryE G McQueen
Mar 1, 1958·The Journal of Clinical Investigation·A K BROWN, W W ZUELZER

❮ Previous
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Citations

Jan 1, 1982·Pediatric Cardiology·W A Neal, M D Mullett
Jan 1, 1986·Pediatric Cardiology·C HammermanA Aldousany
Dec 30, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F CarmonaX Iglesias
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael
Jan 1, 1995·Reproductive Toxicology·A Lione, A R Scialli
Aug 9, 1980·Lancet·H L Halliday
Apr 29, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B Van OvermeireP J Van Reempts
Jan 1, 1991·International Journal of Technology Assessment in Health Care·R I Clyman
Feb 1, 1980·Archives of Disease in Childhood·J A Kitterman
Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·P W Fowlie
May 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·B Van OvermeireK J Van Acker
Dec 1, 1980·The Journal of Pediatrics·S J YaffeC Saccar
Aug 1, 1979·The Journal of Pediatrics·R BhatM Evans
Nov 1, 1987·The Journal of Pediatrics·R I Clyman, D Campbell
Nov 6, 2007·American Journal of Obstetrics and Gynecology·Sanjiv B AminJ Christopher Glantz
Jul 7, 1999·The Journal of Pediatrics·M NarayananR I Clyman
Aug 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Z KatzH Ben Hur
May 1, 1994·The Journal of Pediatrics·J D MerrillM E Norton
Mar 1, 1988·The Journal of Pediatrics·R S AppletonR J Boucek
Nov 25, 1993·The New England Journal of Medicine·M E NortonR I Clyman
Jul 9, 2010·The Cochrane Database of Systematic Reviews·Peter W FowlieWilliam McGuire
May 23, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·J M DavidsonA J Talati
Dec 1, 1987·Developmental Medicine and Child Neurology·D H EvansL N Archer
Mar 27, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Arno F van HeijstK Djien Liem

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