Indomethacin enhances the cytotoxicity of VCR and ADR in human pulmonary adenocarcinoma cells

The Tohoku Journal of Experimental Medicine
S KobayashiS Fujimura

Abstract

The ability of anti-inflammatory agents to modulate cellular sensitivity to anticancer drugs was investigated for pulmonary carcinoma cells in vitro. We examined the drug sensitivity of two pulmonary adenocarcinoma cell lines (76-2, 77-4) in the presence of two drugs, an anticancer drug and an anti-inflammatory agent, for 72 hr by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with 96 well plates. Anticancer drugs used for screening test were cyclophosphamide (CPM), mitomycin C (MMC), adriamycin (ADR), 5-fluorouracil (5FU), vindesine (VDS), cisplatin (CDDP), cytarabine (Ara C), methotrexate (MTX), etoposide (VP-16), and vincristine (VCR). Anti-inflammatory agents examined as modulators to anticancer drugs were aspirin, mefenamic acid, ibuprofen, sulindac, piroxicam, phenacetin, dicrofenac, ketoprofen, tolmetin and indomethacin. Screening tests showed indomethacin to be the most effective modulator, resulting in more than a 3-fold increase in cytotoxicity of VCR as compared with that produced by VCR alone. Study of each of the ten anticancer drugs in combination with indomethacin showed VCR to be the most effective anticancer drug in this combination. In 76-2 cells, the concentration of VCR produci...Continue Reading

References

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Sep 1, 1993·The Tohoku Journal of Experimental Medicine·S KobayashiS Fujimura

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Citations

Dec 25, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C M RichardsonKenneth J O'Byrne
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C P DuffyM Clynes
May 23, 2006·Pharmaceutical Research·S TaetzC-M Lehr
May 18, 1999·The Tohoku Journal of Experimental Medicine·S KobayashiS Fujimura
May 8, 2020·Seminars in Cancer Biology·Anuradha KirtoniaManoj Garg

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