Indomethacin in severe twin-to-twin transfusion syndrome

American Journal of Perinatology
J M JonesM E D'Alton

Abstract

Despite advances in maternal fetal medicine, the management of severe twin-to-twin transfusion syndrome in the second trimester presents a significant challenge. Presently, there is no uniformly accepted management protocol that is available for the treatment of this syndrome. We report the use of indomethacin in three cases of severe twin-to-twin transfusion syndrome in the second trimester. In the three cases of severe twin-to-twin transfusion syndrome no reduction of amniotic fluid in either sac was demonstrated. Two cases were complicated by single intrauterine fetal death within 72 hours of initiating indomethacin therapy. Because of our experience with these three cases, we conclude that indomethacin does not prevent perinatal mortality in patients with severe twin-to-twin transfusion syndrome.

Citations

Jun 29, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R Quintero
Nov 1, 1995·The Journal of Pediatrics·E LoprioreJ P de Leeuw
Jan 31, 2002·Clinics in Perinatology·F D Malone, M E D'Alton
Mar 17, 2004·Obstetrical & Gynecological Survey·Jane Cleary-Goldman, Mary D'Alton
Feb 1, 2014·The Cochrane Database of Systematic Reviews·Devender RobertsSimon Gates
Feb 1, 1995·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J E Dickinson
Feb 1, 1995·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S MeagherB Susil
May 21, 2016·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Rubén A QuinteroRamen H Chmait

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