Indomethacin increases severity of Clostridium difficile infection in mouse model

Future Microbiology
Juan Muñoz-MirallesDaniel Paredes-Sabja

Abstract

To evaluate the effect on the nonsteroidal anti-inflammatory drug indomethacin on Clostridium difficile infection (CDI) severity. Indomethacin was administered in two different mouse models of antibiotic-associated CDI in two different facilities, using a low and high dose of indomethacin. Indomethacin administration caused weight loss, increased the signs of severe infection and worsened histopathological damage, leading to 100% mortality during CDI. Indomethacin-treated, antibiotic-exposed mice infected with C. difficile had enhanced intestinal inflammation with increased expression of KC, IL-1β and IL-22 compared with infected mice unexposed to indomethacin. These results demonstrate a negative impact of nonsteroidal anti-inflammatory drugs on antibiotic-associated CDI in mice and suggest that targeting the synthesis or signaling of prostaglandins might be an approach to ameliorating the severity of CDI.

References

Jul 11, 1992·Lancet·A Gentric, Y L Pennec
Nov 1, 1970·Toxicology and Applied Pharmacology·D A BrodieG E Dagle
Aug 1, 1980·The Journal of Pathology·T H StewartM Orizaga
Jul 1, 1994·The Annals of Pharmacotherapy·R Oren, M Ligumsky
Jan 1, 1996·International Journal of Colorectal Disease·J L Faucheron, R Parc
May 26, 1998·Journal of Clinical Gastroenterology·M Romero-GómezM Castro Fernández
May 13, 2003·Scandinavian Journal of Gastroenterology·P SuenaertP Rutgeerts
Sep 24, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jacques PépinBenoit Cossette
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Sandra DialSamy Suissa
Oct 14, 2008·Gastroenterology·Xinhua ChenCiarán P Kelly
May 22, 2009·Gastroenterology·Jennifer R O'ConnorDale N Gerding
Jan 31, 2012·British Journal of Clinical Pharmacology·Daniel SuissaPaul Brassard
May 9, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L AlcaláUNKNOWN Spanish Clostridium difficile Study Group
Aug 1, 2012·PloS One·Mary A M RogersDavid M Aronoff
Aug 14, 2012·Gastroenterology·Anne F PeeryNicholas J Shaheen
May 8, 2013·BMC Medicine·Mary A M RogersDavid M Aronoff
May 11, 2013·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Adnan Taş, Hacer Celik
May 25, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Raina ShivashankarDarrell S Pardi
Jun 1, 2013·Pharmacoepidemiology and Drug Safety·Yingjun ZhouAndrew N Freedman
Dec 18, 2013·Journal of Emergencies, Trauma, and Shock·Massimo Tonolini
Feb 18, 2014·Current Gastroenterology Reports·Stephanie D Syer, John L Wallace
Jun 24, 2014·Journal of the American Association of Nurse Practitioners·Terri O FowlerBarbara J Edlund
Sep 18, 2014·Anaerobe·Bruno C TrindadeDavid M Aronoff
Oct 9, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Helene RegnaultLaurent Beaugerie
Dec 3, 2014·The Lancet Infectious Diseases·Simon D Goldenberg
Apr 30, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charlesnika T Evans, Nasia Safdar
Oct 21, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M A M Rogers, D M Aronoff
Feb 13, 2016·Headache·Sylvia Lucas
Jul 26, 2016·Canadian Journal of Gastroenterology & Hepatology·Nitipong PermpalungSuthanya Sornprom
Sep 9, 2017·Scientific Reports·Richard B DorshowPhillip I Tarr

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Citations

Aug 28, 2020·Frontiers in Pharmacology·Damian Maseda, Emanuela Ricciotti
Mar 4, 2020·Infection and Immunity·Alexander B SmithJoseph P Zackular
Nov 19, 2021·Journal of the Pediatric Infectious Diseases Society·Larry K KociolekTor Savidge

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Methods Mentioned

BETA
inverted microscopy
ELISA

Software Mentioned

GraphPad Prism

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