Indomethacin inhibits the increased airway responsiveness to histamine following inhalation of C5a des Arg in rabbits

Agents and Actions
N BerendJ L Black

Abstract

It has been shown that inhalation of C5a des Arg increases rabbit airway responsiveness to histamine and that this is associated with an influx of neutrophils into the airway walls. This study was undertaken to see if the augmented response to histamine can be blocked by the cyclo-oxygenase inhibitor indomethacin. Spontaneously breathing, anesthetised rabbits were studied in a volume displacement plethysmograph and pulmonary resistance (R1) was measured using the electrical subtraction technique. Histamine does response curves (HDR) were generated by measuring R1 after serial nubulisation of saline and histamine (1, 3, 10, 30 and 100 mg/ml). Aerosols of either saline or C5a des Arg (1.5 ug/ml) were then inhaled by the animals over a time period of 2 min. An HDR was then repeated 4 hours later. In 9 rabbits the inhalation of C5a des Arg resulted in an upward shift of the repeat HDR: the area under the HDR was significantly greater than under the first HDR (p less than 0.05). In 6 rabbits the repeat HDR 4 hours after saline was shifted downwards (N.S.) indicating some degree of tachyphylaxis. When rabbits were pretreated with indomethacin (5 mg/kg i.v.) the repeat HDR following either C5a des Arg (n = 7) or saline (n = 6) were al...Continue Reading

References

Sep 1, 1979·The Journal of Allergy and Clinical Immunology·R C BoucherJ C Hogg
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Citations

Dec 1, 1988·Agents and Actions·A NicholsonN Berend
Feb 26, 1998·Immunopharmacology·J F Regal
Jan 1, 1989·Pulmonary Pharmacology·J F Regal
Oct 1, 1993·British Journal of Pharmacology·A RobichaudP du Souich
Jan 1, 1987·Clinical and Experimental Pharmacology & Physiology·C L ArmourN Berend

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