PMID: 6969110Dec 1, 1980Paper

Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients

Cancer
T Han, H Takita

Abstract

Indomethacin (prostaglandin synthetase inhibitor) was found to be capable of enhancing the mitogen-induced lymphocyte proliferative responses of healthy subjects and patients with lung cancer. A whole-blood culture technique was used. Indomethacin had no mitogenic activity. We observed a greater enhancement of lymphocyte response by indomethacin in weak responders as compared with strong responders in healthy subjects and lung cancer patients. A greater enhancement was also noted in lung cancer patients with active disease as compared with lung cancer patients in remission. In a separated cell culture system, the indomethacin exerted no effect on purified T cells in the absence of monocytes, while this agent exerted its enhancement effect on T lymphocyte response in the presence of autologous monocytes of lung cancer patients. This suggests that monocytes (suppressor cells) may secrete prostaglandins, which are responsible for the impairment of T lymphocyte response in lung cancer patients.

References

Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·L M Pelus, H R Strausser
May 15, 1977·International Journal of Cancer. Journal International Du Cancer·M ZembalaG L Asherson
Feb 1, 1979·Annals of Internal Medicine·J S GoodwinR P Messner
Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams

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Citations

Jan 1, 1994·Journal of Cellular Biochemistry. Supplement·G J KelloffC C Sigman
Jul 1, 1983·Journal of Clinical Immunology·J L Murray, G M Kollmorgen
Oct 1, 1984·Agents and Actions·N R AckermanP Maloney
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J O'ByrneA L Harris
Dec 2, 1993·International Journal of Cancer. Journal International Du Cancer·M A ShibataS Fukushima
Mar 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Muzammal HussainMuhammad Mahmood Mukhtar
Apr 1, 1982·American Journal of Reproductive Immunology : AJRI·J A Stratton, P J DiSaia
Jun 1, 1982·Arthritis and Rheumatism·Y ChinenH Imura
Dec 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H BlomgrenS Hammarström
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·E T Newbill, M E Johns

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