Indoor Trichoderma strains emitting peptaibols in guttation droplets

Journal of Applied Microbiology
E CastagnoliJ Kurnitski

Abstract

The production of peptaibols, toxic secondary metabolites of Trichoderma, in the indoor environment is not well-documented. Here, we investigated the toxicity of peptaibols in the guttation droplets and biomass of Trichoderma strains isolated from problematic buildings. Seven indoor-isolated strains of T. atroviride, T. trixiae, T. paraviridescens and T. citrinoviride were cultivated on malt extract agar, gypsum boards and paperboards. Their biomass extracts and guttation droplets were highly cytotoxic in resting and motile boar sperm cell assays and in inhibition of somatic cell proliferation assays. The toxins were identified with HPLC/ESI-MS/MS as trichorzianines, trilongins, trichostrigocins and trichostrigocin-like peptaibols. They exhibited toxicity profiles similar to the reference peptaibols alamethicin, trilongins, and trichorzianine TA IIIc purified from T. atroviride H1/226. Particular Trichoderma strains emitted the same peptaibols in both their biomasses and exudate droplets. The trilongin-producing T. citrinoviride SJ40 strain grew at 37°C. To our knowledge, this is the first report of indoor-isolated Trichoderma strains producing toxic peptaibols in their guttation droplets. This report proves that indoor isolate...Continue Reading

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Citations

Apr 11, 2020·International Journal of Molecular Sciences·Piotr SiupkaZofia Piotrowska-Seget
Aug 15, 2018·Microorganisms·Tamás MarikLászló Kredics
Dec 11, 2019·Microorganisms·Saija Hyvönen, Hannu Syrjala
Jul 25, 2021·International Journal of Molecular Sciences·Piotr SiupkaZofia Piotrowska-Seget

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