Induced charge electro-osmotic concentration gradient generator.

Biomicrofluidics
Mranal JainK Nandakumar

Abstract

Biomolecule gradients play an important role in the understanding of various biological processes. Typically, biological cells are exposed to linear and nonlinear concentration gradients and their response is studied for understanding cell growth, cell migration, and cell differentiation mechanisms. Recent studies have demonstrated the use of microfluidic devices for precise and stable concentration gradient generation. However, most of the reported devices are geometrically complex and lack dynamic controllability. In this work, a novel microfluidic gradient generator is presented which utilizes the induced charge electro-osmosis (ICEO) by introducing conducting obstacle in the microchannel. With the ICEO flow component, significant transverse convection can be generated within the microchannel, which can, in turn, be used to create nonlinear as well as asymmetric gradients. The characteristics of the developed concentration gradient are dependent on the interplay between fixed charge electro-osmotic and ICEO flows. It is shown that the proposed device can switch between linear and nonlinear gradients by just altering the applied electric field. Finally, the formation of user-defined concentration profiles (linear, convex, and...Continue Reading

References

Jan 7, 1998·The Journal of Cell Biology·E F FoxmanE C Butcher
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·A GonzalezH Morgan
May 3, 2002·Nature·Guo-li MingMu-ming Poo
Mar 5, 2004·Physical Review Letters·Martin Z Bazant, Todd M Squires
May 13, 2006·Analytical Chemistry·Daniel IrimiaMehmet Toner
Feb 22, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Hui Zhao, Haim H Bau
Dec 21, 2007·Lab on a Chip·Thomas M Keenan, Albert Folch
Aug 21, 2009·Biomicrofluidics·Mranal JainK Nandakumar

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Citations

Apr 9, 2013·Biomedical Microdevices·Ming-Cheng ShihCheng-Hsien Liu
Feb 25, 2011·Analytical Chemistry·Šeila SelimovićAli Khademhosseini

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Software Mentioned

UMFPACK
ICEO
COMSOL

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