Induced hyperproliferation in epithelial cells of mouse prostate by a Western-style diet

Carcinogenesis
L XueM Lipkin

Abstract

In this study the effects of a Western-style diet on epithelial cell proliferation in the prostate and bladder of C57BL/6J mice were investigated. The Western-style diet contained increased fat and low calcium and vitamin D, compared with AIN-76A control diet, at levels simulating human Western diets based on nutrient density. After feeding the Western-style and AIN-76A diets for 5 and 16 weeks, mice were infused with bromodeoxyuridine (BrdU) for 72 h using s.c. implanted osmotic pumps. Findings revealed that in bladder epithelium BrdU labeling indices were not significantly different (P > 0.05) between mice on the control and Western-style diets at both time periods. However, significant increases in BrdU labeling indices occurred in epithelial cells of the anterior (P = 0.024) and dorsal (P = 0.049) lobes, but not in the ventral lobe (P = 0.21), of the mouse prostate after feeding the Western-style diet for 16 weeks, compared with mice on the control diet. These findings demonstrate Western-style diet induction of epithelial cell hyperproliferation in anterior and dorsal lobes of the mouse prostate. The findings further suggest that these nutrients may have a role in human prostatic carcinogenesis, since the anterior and dors...Continue Reading

Citations

Aug 26, 2003·Lipids·Nadia M Attar-BashiAndrew J Sinclair
Oct 8, 1999·Journal of the American College of Nutrition·M Lipkin, H L Newmark
Mar 10, 1999·Journal of the National Cancer Institute·L N KolonelR V Cooney
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Feb 11, 2000·Annals of the New York Academy of Sciences·M Lipkin
Aug 6, 2008·World Journal of Gastroenterology : WJG·Peter-R Holt
Dec 17, 2010·Medical Hypotheses·Ajit Vikram, Gopabandhu Jena
Aug 23, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Glendon M ZinserJoEllen Welsh
May 14, 2016·Nutrition and Cancer·Gisele Aparecida Dionísio LopesMaria Aparecida Marchesan Rodrigues
May 12, 2017·PloS One·Alexander B Opoku-AcheampongBrian L Lindshield
Jan 25, 2002·Annals of the New York Academy of Sciences·S A Lamprecht, M Lipkin
Mar 28, 2002·The American Journal of Clinical Nutrition·David Heber
Jan 31, 2002·World Journal of Gastroenterology : WJG·Martin Lipkin
Apr 28, 2019·Cancer Prevention Research·James C FleetSteven K Clinton

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