Induced hypertension improves regional blood flow and protects against infarction during focal ischemia: time course of changes in blood flow measured by laser Doppler imaging

Neurosurgery
M SmrckaA Ames

Abstract

To characterize changes in regional blood flow (rCBF) during and after a period of arterial occlusion and determine the effect on rCBF and on the extent of infarction when the mean arterial blood pressure is increased during the period of occlusion. rCBF in the middle cerebral artery (MCA) territory of rabbits was monitored using laser Doppler perfusion imaging before, during, and after a 1- or 2-hour period of MCA occlusion, and the size of the infarction was assessed by 2,3,5-triphenyltetrazolamine chloride staining after 2 hours of reperfusion. Test animals, the mean arterial blood pressure of which was increased by 65 mm Hg with intravenous phenylephrine during the ischemia, were compared with control animals that remained normotensive. The laser Doppler perfusion imager (Lisca Developments Co., Linköping, Sweden) scanned a 3-cm2 area of cortex with a resolution of 4 mm2 every 15 minutes. MCA occlusion reduced rCBF to 71 +/- 2% of the control level (n = 24, P < 0.001). Hypertension (HTN) restored rCBF to 84 +/- 3% of the control level (n = 12, P < 0.01), but the HTN-induced improvement diminished with time, so that after 1 hour, there was no longer a significant difference between hypertensive and normotensive animals. HTN ...Continue Reading

References

Oct 1, 1978·Journal of Neurosurgery·F D BrownS Mullan
Jan 1, 1975·Stroke; a Journal of Cerebral Circulation·J V SnyderP Safar
Jul 11, 1975·Archives of Neurology·R C Osburne, J H Halsey
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J ColeR M Schell
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·B KaplanW Pulsinelli
Nov 1, 1990·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D J ColeB I Chi-Lum
Sep 1, 1990·Stroke; a Journal of Cerebral Circulation·D J ColeN H Peckham
Nov 1, 1989·Stroke; a Journal of Cerebral Circulation·J C DrummondH M Shapiro
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W J PowersM E Raichle
Jan 1, 1985·British Journal of Anaesthesia·I Klatzo
Jan 1, 1986·Stroke; a Journal of Cerebral Circulation·L A FernandezT Kaczmar
Dec 1, 1974·Journal of Neurosurgery·S Wernick, O Sugar
Mar 1, 1972·Stroke; a Journal of Cerebral Circulation·G WiseJ Burkholder
Mar 12, 1970·The New England Journal of Medicine·G R Wise
Aug 1, 1967·Archives of Neurology·B W BrawleyW A Kelly
Jan 1, 1984·Journal of Neurosurgery·S HayashiR M Crowell
Jan 1, 1980·Critical Care Medicine·A L BleyaertG R Rao
Nov 1, 1980·Stroke; a Journal of Cerebral Circulation·K A Hossmann, F J Schuier
Mar 1, 1981·Annals of Neurology·K KogureP Scheinberg
Aug 1, 1994·Stroke; a Journal of Cerebral Circulation·G Y Yang, A L Betz
Apr 1, 1993·IEEE Transactions on Bio-medical Engineering·K WårdellG E Nilsson
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N HosomiH Matsuo

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Citations

Mar 15, 2008·Stroke; a Journal of Cerebral Circulation·Hwa Kyoung ShinCenk Ayata
Apr 27, 2011·Expert Review of Cardiovascular Therapy·Bijoy K Menon, Mayank Goyal
Oct 30, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ian R Winship
Dec 14, 2017·International Journal of Molecular Sciences·Mohamad El Amki, Susanne Wegener
Jul 19, 2017·Frontiers in Neurology·Robert W RegenhardtThabele M Leslie-Mazwi
Jun 10, 2021·Stroke; a Journal of Cerebral Circulation·Marilyn J Cipolla

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