Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome

Endocrinology
A BoelenW M Wiersinga

Abstract

Interleukin-6 (IL-6) administration to human subjects or experimental animals induces changes in thyroid hormone metabolism resembling those in the sick euthyroid syndrome. Furthermore, the decrease in serum T3 during illness is significantly related to serum IL-6 concentrations. These findings suggest, but do not prove, a causal role for IL-6 in the development of the low T3 syndrome. The aim of the present study was to evaluate the role of IL-6 in the development of the sick euthyroid syndrome in IL-6 knock-out (IL-6(-/-)) mice compared to that in wild-type mice (IL-6(+/+)). Illness was induced in IL-6(-/-) and IL-6(+/+) mice by 1) administration of bacterial endotoxin (LPS), 2) infection with Listeria monocytogenes, and 3) turpentine injection in both hind limbs. Food intake was kept similar in both groups in all three experiments. Serial measurements were made of serum IL-6, tumor necrosis factor-alpha, T3, T4, corticosterone, and liver 5'-deiodinase (5'-DI) messenger RNA (mRNA) for 24 h (LPS), 96 h (L. monocytogenes), and 48 h (turpentine). Serum IL-6 increased in response to all stimuli in IL-6(+/+) mice, but not in IL-6(-/-) mice. Serum tumor necrosis factor-alpha was induced by LPS in both groups to a similar extent, bu...Continue Reading

Citations

Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Roberto RocchiPatrizio Caturegli
Jun 22, 2002·Molecular and Cellular Biology·Subhashini ChandrasekharanEdison T Liu
Apr 9, 2008·The Journal of Clinical Endocrinology and Metabolism·Irwin Klein, Sara Danzi
Feb 26, 2011·Age·Maarten P RozingDiana van Heemst
Sep 8, 2006·Journal of Hypertension·Carmine ZoccaliGiuseppe Seminara
Sep 12, 2012·International Urology and Nephrology·Usama ElewaAlberto Ortiz
Oct 23, 2010·European Journal of Clinical Investigation·Theodora A PappaMaria Alevizaki
Nov 21, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·V LubranoG Iervasi
Aug 4, 2016·Scientific Reports·Constanza Contreras-JuradoAna Aranda
Sep 25, 2015·Metallomics : Integrated Biometal Science·J MartitzL Schomburg
May 19, 2006·Expert Opinion on Therapeutic Targets·Beverly E Barton
Apr 9, 2019·Endocrine Connections·Madalena von HafeAdelino Leite-Moreira
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·D A Papanicolaou, A N Vgontzas
May 25, 2006·The Journal of Clinical Endocrinology and Metabolism·Luigi FontanaBhartur N Premachandra
Aug 12, 2020·Molecular and Cellular Biochemistry·Laura SabatinoGiorgio Iervasi
Dec 16, 2020·Journal of Endocrinological Investigation·E Fliers, A Boelen
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M D Brennan, R S Bahn
Jan 15, 2002·The Journal of Biological Chemistry·Christelle CeboJean-Pierre Zanetta
Feb 10, 2021·Journal of Endocrinological Investigation·L CroceL Chiovato
Feb 10, 1999·The American Journal of Physiology·T van der PollS F Lowry
Dec 2, 2021·Journal of Endocrinological Investigation·C SparanoL Petrone

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