PMID: 11931258Apr 5, 2002Paper

Induced immunity against the mosquito Anopheles stephensi (Diptera: Culicidae): effects of cell fraction antigens on survival, fecundity, and plasmodium berghei (Eucoccidiida: Plasmodiidae) transmission

Journal of Medical Entomology
A P Almeida, P F Billingsley

Abstract

Two subeellular fractions from the midgut of the malaria mosquito Anopheles stephensi (Liston) were used to immunize BALB/c mice. Mice were subsequently infected with the rodent malaria parasite Plasmodium berghei (Vineke & Lips), and the effects of anti-mosquito immunity on mosquito survival and fecundity and on parasite transmission were investigated. Mosquitoes were infected directly from mice (in vivo) or by feeding cultured ookinetes through a membrane (in vitro). Infections were monitored by counting oocysts on the midgut wall. Microvilli extracts induced a strong and partially specific antibody reaction against the midgut, which was manifest as decreased survival in in vivo fed mosquitoes and reduced fecundity in both kinds of feeding. Antisera against microvilli reduced the mean intensity of P. berghei oocysts when fed in vitro, while mosquitoes fed antiserum against basolateral plasma membranes in vivo, showed higher oocyst burdens.

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Citations

Sep 22, 2010·Vector Borne and Zoonotic Diseases·Jeroen KortekaasRob J M Moormann
Feb 12, 2011·BMC Genomics·Lorena TorresJosé de la Fuente
Feb 21, 2009·Parasitology Research·Mario CanalesJosé de la Fuente
Jan 8, 2013·Vaccine·Juan A Moreno-CidUNKNOWN SUB/AKR Vaccine Study Group
Aug 6, 2008·Trends in Parasitology·Peter F BillingsleyJason L Rasgon
Jul 3, 2010·Vaccine·Carlos R PrudencioJosé de la Fuente
Jun 15, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Derrick K MathiasRhoel R Dinglasan
May 12, 2016·Parasites & Vectors·Alba N Lecona-ValeraMaría C Rodríguez
Mar 18, 2006·Parasite Immunology·P F BillingsleyC Drakeley
Dec 22, 2020·PLoS Pathogens·Perrine MarcenacFlaminia Catteruccia

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