Induced mild hypothermia in post-cardiopulmonary bypass vasoplegia syndrome

Annals of Cardiac Anaesthesia
Mukesh TripathiKailash Chandra Pant

Abstract

The state of vasoplegia in immediate post-cardiopulmonary bypass period is characterized by severe hypotension, supranormal cardiac output, low systemic vascular resistance (SVR), and resistance to vasoconstrictors. We could successfully use induced mild hypothermia to increase SVR, and could avoid very high doses of nor-epinephrine (>0.3 mcg/kg/min) in the background of severe pulmonary hypertension (systolic pulmonary pressure> 90 mmHg). Its effects such as decreased oxygen demand, positive inotropy and better right ventricle performance probably helped to improve oxygenation in presence of pulmonary oedema.

References

Apr 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·J J LehotS Estanove
Apr 1, 1994·Acta Anaesthesiologica Scandinavica·T WetterbergS Steen
Jan 1, 1993·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G AgnolettiR Ferrari
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·B E Miller, J H Levy
May 1, 2001·Basic Research in Cardiology·J WeisserB Pieske
Jun 1, 2001·The Annals of Thoracic Surgery·A Mekontso-DessapD Y Loisance
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Rainer G LeyhAxel Haverich
Jan 16, 2007·Canadian Journal of Physiology and Pharmacology·T V Kondratiev, T Tveita

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