Induced mild systemic inflammation is associated with impaired ability to improve cognitive task performance by practice

Psychophysiology
Nicola J PaineJet J C S Veldhuijzen van Zanten

Abstract

Elevated inflammatory levels are linked to poorer cognition, but experimental confirmation is lacking. This report examined associations between cognitive performance and inflammation induced by exercise and vaccination. Thirty-six (exercise N = 18, vaccination N = 18) healthy males completed a paced auditory serial addition test (PASAT), which is a multifaceted measure of cognitive function. The task was completed in placebo and elevated inflammation states. Improvements in PASAT performance were related to inflammation. In the exercise study, IL-6 during the first PASAT negatively correlated with PASAT improvement (p = .022). In the vaccination study, increases in C-reactive protein between PASATs correlated with reduced PASAT improvement (p < .001). Inflammation was linked to reduced improvements in cognitive performance. Further research should identify the specific cognitive functions affects and the underlying mechanisms.

Citations

Apr 1, 1977·Perceptual and Motor Skills·D Gronwall
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Oct 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·D Gronwall, P Wrightson
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C J HeyserL H Gold
Apr 29, 2000·The Journal of Head Trauma Rehabilitation·N K MadiganA Averill
May 16, 2001·Archives of General Psychiatry·Abraham ReichenbergT Pollmächer
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark A Febbraio, Bente Klarlund Pedersen
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Adam SteensbergBente Klarlund Pedersen
Feb 13, 2003·International Journal of Sports Medicine·D S WilloughbyC Bois
Jun 11, 2004·Psychophysiology·Jet J C S Veldhuijzen van ZantenDouglas Carroll
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Apr 27, 2005·Neurology·M G DikP Eikelenboom
Jun 21, 2005·Brain, Behavior, and Immunity·Karen Suárez KrabbeHelle Bruunsgaard
Nov 18, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tom N Tombaugh
Jun 2, 2006·Springer Seminars in Immunopathology·Burkhard Möller, Peter M Villiger
Oct 5, 2006·Medicine and Science in Sports and Exercise·Stephan SorichterAloys Berg
Nov 30, 2006·Psychosomatic Medicine·Anna L MarslandStephen B Manuck
Mar 14, 2007·Experimental Gerontology·Anita H J van den BiggelaarRudi G J Westendorp
Mar 16, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Janet L ShucardDavid W Shucard
May 12, 2007·Journal of the American Geriatrics Society·Miranda T SchramRudi G J Westendorp
Jun 1, 2007·Age and Ageing·Pirjo KomulainenRainer Rauramaa
Sep 4, 2007·Current Neurology and Neuroscience Reports·Rachel A Whitmer
Jun 3, 2008·Biological Psychiatry·Anna L MarslandAhmad R Hariri
Jul 25, 2008·Nature·Ruslan Medzhitov
Sep 9, 2008·Psychoneuroendocrinology·David GimenoArchana Singh-Manoux
Nov 11, 2008·Neuroscience and Biobehavioral Reviews·J McAfoose, B T Baune
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
May 30, 2009·Journal of cardiology·Epaminondas Zakynthinos, Nikolitsa Pappa
Sep 16, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rosebud O RobertsRonald C Petersen
Dec 10, 2009·Medicine and Science in Sports and Exercise·Sarah R JackmanKevin D Tipton
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Gareth J PadfieldNicholas L Mills
Sep 30, 2010·Neurobiology of Learning and Memory·Jan-Sebastian GrigoleitManfred Schedlowski
Jan 25, 2011·Behavior Genetics·Riccardo E MarioniJackie F Price
Aug 16, 2011·Brain, Behavior, and Immunity·Hui Hua ChangPo See Chen
Jun 30, 2012·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Andrea C SartoriMichael Crowe
Sep 25, 2012·Frontiers in Neuroendocrinology·Jennifer C Felger, Andrew H Miller

Related Concepts

C-reactive Protein Measurement
Exercise, Isometric
Memory for Designs Test
Vaccination
Interleukin-6, human
Practice (Psychology)
Interleukin-6 Binding Activity
Inflammation
IL6 gene
Interleukin-6

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.