Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury

Neural Regeneration Research
Corinne A Lee-Kubli, Paul Lu

Abstract

The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell therapies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as addressing potential mechanisms, future perspectives and challenges.

References

May 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hans S KeirsteadOswald Steward
Oct 4, 2006·Experimental Neurology·Paul LuMark H Tuszynski
Jul 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ronaldo M IchiyamaV Reggie Edgerton
Aug 12, 2008·Molecular and Cellular Neurosciences·Nina FainsteinTamir Ben-Hur
Oct 11, 2008·Science·Keisuke OkitaShinya Yamanaka
Apr 29, 2009·Cell Stem Cell·Hongyan ZhouSheng Ding
Aug 4, 2009·Nature Neuroscience·Laura Taylor AltoMark H Tuszynski
Jan 29, 2010·Nature·Thomas VierbuchenMarius Wernig
Jun 4, 2010·Cold Spring Harbor Perspectives in Biology·Roman J GigerMark H Tuszynski
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Osahiko TsujiHideyuki Okano
Apr 28, 2011·Proceedings of the National Academy of Sciences of the United States of America·Janghwan KimSheng Ding
May 26, 2011·Neuron·Steve S W HanKevin C Eggan
May 28, 2011·Nature·Zhiping P PangMarius Wernig
Jun 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ulrich PfistererMalin Parmar
Jul 27, 2011·Current Gene Therapy·Juliane W SchottAxel Schambach
Aug 20, 2011·Cell Stem Cell·Esther Y SonKevin Eggan
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Satoshi NoriHideyuki Okano
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ernesto LujanMarius Wernig
Mar 27, 2012·Cell Stem Cell·Dong Wook HanHans R Schöler
Mar 27, 2012·Cell Stem Cell·Marc ThierFrank Edenhofer
Oct 27, 2012·Handbook of Clinical Neurology·S Sakiyama-ElbertA R Harvey
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Olof TorperMalin Parmar
Apr 16, 2013·Progress in Neurobiology·Bridgette D SempleLinda J Noble-Haeusslein
May 31, 2013·Journal of Neural Transmission·Andreas Hermann, Alexander Storch
Aug 10, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrea J Mothe, Charles H Tator
Nov 26, 2013·Progress in Neurobiology·Nuno A SilvaAntónio J Salgado
Jan 30, 2014·Protein & Cell·Jiani CaoTongbiao Zhao
Feb 27, 2014·Nature Communications·Zhida SuChun-Li Zhang
Mar 4, 2014·Progress in Neurobiology·Jason R PlemelWolfram Tetzlaff
Mar 22, 2014·Nature Protocols·Sung Min KimDong Wook Han

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Citations

Jan 16, 2016·Cellular and Molecular Life Sciences : CMLS·John BiancoAnne des Rieux
Dec 31, 2016·International Journal of Molecular Sciences·Marina GazdicMiodrag Stojkovic

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