Induced pluripotent stem cells: from derivation to application in biochemical and biomedical research

Biochemistry. Biokhimii︠a︡
E V Novosadova, I A Grivennikov

Abstract

This review considers different methods for obtaining induced pluripotent stem (iPS) cells and their use in biochemical and biomedical research. Some viral and nonviral methods for obtaining iPS cells are described. Basic factors involved in reprogramming are considered. It is also demonstrated that the most suitable source of iPS cells are skin fibroblasts. Properties of iPS cells and embryonic stem cells are compared, and some advantages of iPS cells for biological and biomedical investigations are emphasized. The possibilities for application of iPS cells in the development of cell models of some neurodegenerative diseases, drug screening, and cell therapy are also considered.

References

Nov 6, 1998·Science·J A ThomsonJ M Jones
Jan 4, 2001·The International Journal of Biochemistry & Cell Biology·D T DangV W Yang
Oct 9, 2002·Genes & Development·Troy A BaudinoJohn L Cleveland
Nov 20, 2002·World Journal of Gastroenterology : WJG·Nan WangMin Wu
Apr 1, 2003·Molecular and Cellular Biology·Yoshimi TokuzawaShinya Yamanaka
Aug 7, 2003·Biochemical and Biophysical Research Communications·Shunsuke OhnishiTeruhiko Yoshida
Dec 12, 2003·Cancer Cell·Sharon GidekelEli Pikarsky
May 4, 2004·Molecular and Cellular Biology·Satoru MiyagiAkihiko Okuda
Jul 2, 2004·Nature Reviews. Cancer·Jagruti H PatelSteven B McMahon
Jul 9, 2004·Cytogenetic and Genome Research·C DongP Koopman
Mar 8, 2005·Stem Cells·Holm ZaehresGeorge Q Daley
Oct 13, 2005·Carcinogenesis·Daoyan WeiKeping Xie
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Michele Boiani, Hans R Schöler
Jan 10, 2006·Developmental Cell·Eran MeshorerTom Misteli
Aug 15, 2006·Seminars in Cancer Biology·Chi V DangFeng Li
Aug 29, 2006·Seminars in Cancer Biology·Victoria H Cowling, Michael D Cole
Sep 7, 2006·Molecular and Cellular Biology·Yuhki NakatakeHitoshi Niwa
Nov 23, 2006·The Journal of Pathology·L ChengL H J Looijenga
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Aug 19, 2007·Cancer Cell·Ronald Lebofsky, Johannes C Walter
Nov 22, 2007·Science·Junying YuJames A Thomson
Dec 7, 2007·Nature Biotechnology·Masato NakagawaShinya Yamanaka
Dec 11, 2007·Nature Genetics·Tsung-Cheng ChangJoshua T Mendell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.