Induced preference or conditioned aversion for sodium chloride in rats with chronic bile duct ligation

Physiology & Behavior
J R LaneD A Fitts

Abstract

We examined whether a learned aversion to saline could account for the reduction in saline intake produced by bile duct ligation (BDL) in rats and whether increased saline intake by BDL rats was associated with hypotension. In three experiments, rats were given continuous access to water in choice with saline after surgery. In Experiment 1, rats were deprived of food and fluid for 24 h and then given 2-h access to either 0.15 or 0.3 M saline. Rats received a BDL or sham-ligation immediately (paired) or 48 h after (nonpaired) the 2-h bout of saline ingestion. The results show that nonpaired BDL rats increased their daily saline intake relative to nonpaired sham-ligated or paired BDL rats approximately 1-4 weeks after surgery. In Experiment 2, when water and either cherry or grape Kool-Aid (0.05% w/v) dissolved in 0.15 M saline to distinguish the flavor of the solution was offered prior to surgery, BDL rats reduced their ingestion of grape-flavored saline after surgery regardless of whether they were exposed to grape- or cherry-flavored saline prior to surgery. In Experiment 3, when rats were offered water and 0.3 M saline 48 h after surgery, BDL rats ligated for 4 weeks increased their saline intake relative to sham-ligated cont...Continue Reading

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Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·J R LaneD A Fitts

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Citations

Oct 31, 2001·Brain Research·E S Na, D A Fitts
Jul 27, 2000·The American Journal of Clinical Hypnosis·B Brady, L Stevens
May 2, 2003·The American Journal of Clinical Hypnosis·Larry StevensPatrick McManus
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Helané WahbehHeather Zwickey
Mar 29, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Helané WahbehDan Zajdel
Jan 31, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Augusto WeberPaulo Gans
Mar 30, 2004·The Journal of Physiology·Margaret J SullivanJ Thomas Cunningham

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