Induced production of cytochalasans in co-culture of marine fungus Aspergillus flavipes and actinomycete Streptomyces sp

Natural Product Research
Liyan YuZhongjun Ma

Abstract

Abstarct Secondary metabolites profiles of co-culture of Aspergillus flavipes and Streptomyces sp. that isolated from the same habitat showed an induced production of a series of cytochalasans (five aspochalasins and rosellichalasin, determined by MS and NMR analysis). These cytochalasans were found to be produced by A. flavipes in LC-MS comparison analysis, and biological activity assays revealed that they were able to cause cytotoxic effects against Streptomyces sp. within a wide range of concentrations without causing any effect to the producer A. flavipes, which favoured the producer in competition. Further induction mechanism study applying membrane-separated culture and morphology study with scanning electron microscopy (SEM) suggested that the successful induction of active secondary metabolites required microbial physical contact.

References

Oct 1, 1982·The Journal of Antibiotics·M FlashnerS W Tanenbaum
Apr 1, 1993·The Journal of Antibiotics·N NaruseT Oki
Jun 28, 2001·The Journal of Antibiotics·T TomikawaY Hayakawa
Sep 24, 2002·The Journal of Antibiotics·Taijiro TomikawaYoichi Hayakawa
Dec 29, 2004·Journal of Asian Natural Products Research·Ting JiangWen-Han Lin
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·Juan E González, Neela D Keshavan
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Volker SchroeckhAxel A Brakhage
Apr 23, 2010·Natural Product Reports·Kirstin ScherlachChristian Hertweck
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hans-Wilhelm NützmannAxel A Brakhage
Nov 10, 2011·Toxins·Stephen O Duke, Franck E Dayan
Oct 31, 2012·Natural Product Research·Ana Paula C TelesJacqueline A Takahashi
Jul 3, 2013·Annual Review of Microbiology·Kirstin ScherlachChristian Hertweck
Jun 20, 2014·Natural Product Research·Jinzhong XuXianwen Yang
Oct 2, 2014·Marine Drugs·Ying LiuJinzhong Xu

❮ Previous
Next ❯

Citations

Jul 20, 2019·Journal of Natural Medicines·Takahiro JomoriMasayoshi Arai
Jul 26, 2018·Marine Drugs·Stefano RomanoAlan D W Dobson
Jan 18, 2018·Natural Product Reports·John W BluntMichèle R Prinsep
Nov 3, 2020·Applied Biochemistry and Biotechnology·Preeti BharatiyaAbhijeet S Kate
Apr 8, 2021·Journal of Industrial Microbiology & Biotechnology·Ji Hun KimByung-Kwan Cho
Jan 19, 2020·Biotechnology Advances·Divya AroraSamuel Bertrand

❮ Previous
Next ❯

Datasets Mentioned

BETA
KJ729120
KP760851

Methods Mentioned

BETA
column chromatography
nuclear magnetic resonance

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.