Induced production of nitric oxide, tumor necrosis factor, and interleukin-6 in RAW 264.7 macrophages by streptomycetes from indoor air of moldy houses

Archives of Environmental Health
M R HirvonenK Savolainen

Abstract

Dampness and mold growth in buildings cause spore generation into indoor air, which is associated with respiratory tract disorders. Specific agents or cellular mechanisms of diseases have not yet been identified. In this study, airborne spores of Streptomyces sp., isolated from moldy houses, stimulated RAW264.7 macrophages, which produced tumor necrosis factor alpha and interleukin-6 and induced the expression of inducible nitric oxide synthase, with subsequent nitric oxide production. Spores of other microorganisms typically found in moldy houses did not markedly increase the production of these inflammatory mediators. The data implied a mechanism by which Streptomyces sp. may lead to respiratory tract disorders in individuals who live in moldy houses.

References

May 1, 1992·Immunology Today·H Kolb, V Kolb-Bachofen
Oct 1, 1992·Allergy·B Brunekreef
Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Mar 1, 1991·Immunology Today·F Y Liew, F E Cox
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L N HeissW E Goldman
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Apr 1, 1995·Chemical Research in Toxicology·T deRojas-WalkerS R Tannenbaum
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·N W KooyJ S Beckman
Oct 1, 1993·Thorax·P J Barnes, M G Belvisi
Jan 15, 1994·Lancet·S A KharitonovP J Barnes
May 1, 1996·The Biochemical Journal·M R HirvonenE G Lapetina
Nov 1, 1994·Trends in Endocrinology and Metabolism : TEM·J D LaskinD L Laskin

❮ Previous
Next ❯

Citations

Sep 21, 2000·Environmental Toxicology and Pharmacology·K HuttunenM Hirvonen
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·M R HirvonenA Nevalainen
Aug 10, 2005·Inhalation Toxicology·Timo MurtoniemiMaija-Riitta Hirvonen
Nov 26, 2014·Particle and Fibre Toxicology·Mikko S HappoMaija-Riitta Hirvonen
May 7, 2013·Clinical Therapeutics·Stephen J Genuis
Nov 17, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·James J PestkaJack R Harkema
Jan 1, 2002·FEMS Microbiology Ecology·Merja SuutariAino Nevalainen
May 20, 2003·Journal of Applied Microbiology·T MurtoniemiM-R Hirvonen
Jan 8, 2003·Environmental Health Perspectives·Kati HuttunenMaija-Riitta Hirvonen
Jan 11, 2003·Clinical and Diagnostic Laboratory Immunology·J JussilaM-R Hirvonen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.