Induced sputum in children with newly diagnosed mild asthma: the effect of 6 months of treatment with budesonide or disodium cromoglycate

Allergy
P RytiläM Turpeinen

Abstract

There are few controlled studies on the effects of anti-inflammatory treatment on airway inflammation in newly diagnosed childhood asthma. Sixty children with newly diagnosed mild persistent asthma, 5-10 years of age, and 17 healthy control subjects were studied. Asthmatic children were randomized into an open study with two treatment groups: (1) budesonide 400 microg twice daily for 1 month, 200 microg twice daily for 5 months and (2) disodium cromoglycate (DSCG) 10 mg three-times daily for 6 months. All exacerbations were treated with budesonide 400 microg twice daily for 2 weeks. Symptoms and lung function were recorded throughout the study. Sputum induction was safe and the overall success rate was 71%. This improved with age and decreased after treatment. At baseline, the asthmatic children had more eosinophils in blood (0.26 vs 0.18 x 10(9)/l, P = 0.03) and sputum (1.1 vs 0.0 %, P = 0.0001) than the control subjects. The numbers of sputum eosinophils correlated with bronchial responsiveness (R = -0.58, P = 0.0002). Eosinophils were higher in children with atopic asthma than with nonatopic asthma (P < 0.0001), and in children with a history wheezing than in children without wheezing (P = 0.02). Six months of budesonide tre...Continue Reading

References

Mar 1, 1992·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Sep 15, 1994·The New England Journal of Medicine·T HaahtelaA Sovijärvi
May 1, 1993·The American Review of Respiratory Disease·J V FahyH A Boushey
Feb 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·R SorvaT Haahtela
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·A S PelkonenM Turpeinen
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J O WarnerP Pohunek
Jul 7, 1999·Lancet·I D PavordA J Wardlaw
Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Oct 4, 2002·The European Respiratory Journal. Supplement·R DjukanovićF E Hargreave
Oct 4, 2002·The European Respiratory Journal. Supplement·J C KipsP J Sterk
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Donald N R PaynePeter K Jeffery

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Citations

Dec 17, 2005·Current Opinion in Pulmonary Medicine·Annemie L M Boehmer, Peter J F M Merkus
Aug 19, 2006·American Journal of Respiratory and Critical Care Medicine·Angelo BarbatoMarina Saetta
Mar 20, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Noora LouhelainenAnna Pelkonen
Feb 11, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Young YooJi Tae Choung
Nov 3, 2009·Paediatric Respiratory Reviews·Bart L Rottier, Eric J Duiverman
Jun 17, 2006·Pediatric Pulmonology·Albert M LiTai F Fok
Oct 24, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C J LovettP G Gibson
Dec 17, 2005·Pulmonary Pharmacology & Therapeutics·Fabio L M Ricciardolo
Sep 14, 2015·Revista chilena de pediatría·Alberto Vidal G

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