Induced Stem Cells as a Novel Multiple Sclerosis Therapy

Current Stem Cell Research & Therapy
Chong XieGuang-Xian Zhang

Abstract

Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or mesenchymal stem cells is a potential therapy for MS thanks to their capacity for cell repopulation as well as for their immunomodulatory and neurotrophic properties. Induced pluripotent stem cell (iPSC), an emerging cell source in regenerative medicine, is also being tested for the treatment of MS. Remarkable improvement in mobility and robust remyelination have been observed after transplantation of iPSC-derived neural cells into demyelinated models. Direct reprogramming of somatic cells into induced neural cells, such as induced neural stem cells (iNSCs) and induced oligodendrocyte progenitor cells (iOPCs), without passing through the pluripotency stage, is an alternative for transplantation that has been proved effective in the congenital hypomyelination model. iPSC technology is rapidly progressing as efforts are being made to increase the efficiency of iPSC therapy and reduce its potential side effects. In this review, we discuss the recent advances in application of stem...Continue Reading

Citations

Nov 30, 2019·Journal of Neurochemistry·Osamu ImamuraKunio Takishima
Aug 24, 2019·Current Stem Cell Research & Therapy·Tannaz Akbari KolagarSeyed Esmaeil Khoshnam
Dec 22, 2019·Stem Cell Reviews and Reports·Raffaella Adami, Daniele Bottai
Jun 18, 2021·International Journal of Endocrinology·Qiulan HuangJianping Liu
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jayden A SmithStefano Pluchino
May 10, 2017·Bioconjugate Chemistry·Johoon KimDavid P Cormode

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