PMID: 59149Jul 10, 1976

Induced tolerance in cold urticaria caused by cold-evoked histamine release

C B Bentley-PhillipsM W Greaves


The interrelations between cold sensitivity and release of histamine and other mediators in five patients with cold urticaria undergoing cold tolerance treatment were studied. Tolerance to cold was produced in all patients by repeated cold exposure. In four patients tolerance was maintained by once daily exposures. In the fifth patient 4-hourly exposures were necessary. Cold sensitivity was associated with histamine release in venous blood draining urticated skin. No prostaglandin activity was detected, and low concentrations of kinin activity were found in blood draining the normal and exposed skin of healthy subjects as well as in patients with cold urticaria. After induction of tolerance, no histamine release occurred on challenge by cold. Relapse of sensitivity was associated with reappearance of histamine release on challenge. The conclusion that tolerance is due to depletion of histamine stores in skin after repeated cold exposure was supported by diminished wealing in response to injection of a histamine liberator (compound 48/80) in cold-tolerant skin.


Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·R J HarvimaJ E Fräki
Oct 1, 1980·The Journal of Allergy and Clinical Immunology·S InoueS Nagata
Apr 27, 2000·Allergy·M W Greaves
Aug 1, 1977·The British Journal of Dermatology·M W GreavesI Robertson
Jul 1, 1978·The British Journal of Dermatology·R A EadyM W Greaves
Jul 1, 1979·The British Journal of Dermatology·A S Highet, D M Titterington
Aug 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J Rimmer, Martin K Church
Jul 9, 2010·Pediatric Dermatology·Gabriel F Sciallis, Esther H Krych
Jul 15, 2005·Skin Pharmacology and Physiology·M W Greaves
Jan 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N H MaltbyG W Taylor
May 1, 1988·The British Journal of Dermatology·A D OrmerodM W Greaves
Oct 1, 1988·The British Journal of Dermatology·M W Greaves
Mar 1, 1984·The British Journal of Dermatology·T M KeaheyB Zweiman
Nov 3, 1979·Lancet·A K BlackM W Greaves
May 1, 1982·Clinical and Experimental Dermatology·A K Black
Jul 1, 1980·The British Journal of Dermatology·N EftekhariM W Greaves
Nov 25, 2000·Hospital Medicine·M W Greaves
Jan 1, 1985·American Journal of Industrial Medicine·A K Black
Dec 1, 1980·Clinical and Experimental Dermatology·M W Greaves
Sep 1, 1981·The British Journal of Dermatology·R G SibbaldM W Greaves
Aug 1, 1981·The Australasian Journal of Dermatology·M W Greaves
Aug 1, 1981·The Australasian Journal of Dermatology·A R Ahmed, R Moy
Nov 1, 1981·International Journal of Dermatology·A R Ahmed, R Moy
Jan 1, 1982·Scandinavian Journal of Plastic and Reconstructive Surgery·T Waris, K Kyösola
Apr 1, 1985·Journal of the Royal Society of Medicine·P E ElphinstoneM W Greaves
Jun 22, 2017·Current Allergy and Asthma Reports·Mario Sánchez-BorgesArnaldo Capriles-Hulett
Oct 1, 1978·International Journal of Dermatology·W A Akers, D N Naversen
Oct 1, 1980·The Journal of Dermatology·M W Greaves
Jun 1, 1980·International Journal of Dermatology·C A Ramsay
Nov 1, 1996·The Journal of Dermatology·M W Greaves, R A Sabroe
Feb 13, 2018·Immunological Reviews·Martin K ChurchMarcus Maurer
Nov 1, 1979·International Journal of Dermatology·S C Rogers, J S Comaish
Feb 1, 1980·British Journal of Clinical Pharmacology·J L HawkM W Greaves

Related Concepts

Cold Temperature
Histamine Release
Cold Therapy

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