Inducibility of atrial and ventricular arrhythmias along the ligament of marshall: role of autonomic factors

Journal of Cardiovascular Electrophysiology
Jiaxiong LinSunny S Po

Abstract

The mechanism(s) underlying atrial fibrillation (AF) initiation along the ligament of Marshall (LOM) remains controversial. We sought to examine the role of the autonomic nervous system in arrhythmogenesis along the LOM. In 31 anesthetized dogs, a left thoracotomy exposed the LOM. During atrial pacing, high-frequency stimulation (HFS: 200 Hz, 0.1 ms pulse width, 40 ms duration, 0.6-12 V) was delivered during atrial refractoriness to different sites of LOM (LOM(CS)= near coronary sinus; LOM(LIPV)= near left inferior pulmonary vein; LOM(LS-LIPV)= between LIPV and left superior pulmonary vein (LSPV); LOM(LSPV)= near LSPV). HFS was repeated after intravenous administration of esmolol (1 mg/kg; n = 9) or atropine (2 mg; n = 12). Norepinephrine (10(-7) M, 0.4 cc) was injected into LOM(LSPV) (n = 5). The median voltages for HFS to induce AF were 3.2 V, 3.2 V, 8.0 V*(,double dagger), and 12 V*(,double dagger) at LOM(CS), LOM(LIPV), LOM(LS-LIPV), and LOM(LSPV), respectively (*P < 0.01, compared with LOM(CS) and double dagger P < 0.01, compared with LOM(LIPV)). Esmolol or atropine markedly increased the threshold for AF induction. Ventricular tachycardias (VT) and accelerated junctional rhythm were induced in 8 of 12 and 6 of 12 dogs aft...Continue Reading

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Citations

Jun 15, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Jun MaoSunny S Po
Jan 19, 2016·Progress in Biophysics and Molecular Biology·Crystal M RipplingerDominik Linz
Nov 19, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Moisés Rodríguez-MañeroMiguel Valderrábano
Jun 24, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Paul G A Volders
Mar 17, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jay Tiongson, Sanjiv M Narayan
Dec 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi NakagawaWarren M Jackman
Mar 21, 2012·Journal of Cardiovascular Electrophysiology·Amish S DaveMiguel Valderrábano
Dec 22, 2009·Journal of Cardiovascular Electrophysiology·Raphael RossoJonathan M Kalman
Mar 11, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Gang WuYong-Mei Cha
Feb 25, 2014·Journal of the American College of Cardiology·José L Báez-EscuderoMiguel Valderrábano
May 27, 2014·Circulation. Arrhythmia and Electrophysiology·Jun MaoXingpeng Liu
Oct 2, 2013·Circulation·S Rasika Wickramasinghe, Vickas V Patel
Sep 12, 2020·Pacing and Clinical Electrophysiology : PACE·Bo HeZhibing Lu
Feb 10, 2017·Pacing and Clinical Electrophysiology : PACE·Jen-Hung HuangYi-Jen Chen
Dec 20, 2019·Pacing and Clinical Electrophysiology : PACE·Deepak SalujaJames Coromilas
Dec 20, 2018·Clinical Case Reports·Laurence van der Haert, Dominique Blommaert
Mar 28, 2019·Frontiers in Physiology·Yanqiu LaiHong Jiang
Jul 7, 2010·Expert Review of Cardiovascular Therapy·Vickas V Patel
Mar 31, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Miguel Valderrábano
May 25, 2021·Frontiers in Cardiovascular Medicine·Fei LiuYunlong Xia

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